Publication:
Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa

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Issued Date

2012

Resource Type

Article

File Type

application/pdf

ISSN

1934578X

DOI

10.1177/1934578x1200700507

Other identifier(s)

2-s2.0-84861505544

Rights Holder(s)

Scopus

Bibliographic Citation

Natural Product Communications. Vol 7, No.5 (2012), p.575-580

Suggested Citation

Wangchuk P., Keller P.A., Pyne S.G., Sastraruji T., Taweechotipatr M., Rattanajak R., Tonsomboon A., Kamchonwongpaisan S. Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa. Natural Product Communications. Vol 7, No.5 (2012), p.575-580. doi:10.1177/1934578x1200700507 Retrieved from: https://hdl.handle.net/20.500.14740/7070

Title

Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa

Author(s)

Wangchuk P.
 Keller P.A.
 Pyne S.G.
 Sastraruji T.
 Taweechotipatr M.
 Rattanajak R.
 Tonsomboon A.
 Kamchonwongpaisan S.

Abstract

The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. The phytochemical study resulted in the isolation of nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) and bicuculline (9), with complete NMR data for 2 and 3 provided here for the first time. Crude extracts exhibited significant anti-inflammatory (p<0.01) activity against TNF-α production in LPS activated THP-1 cells. The acetylcholinesterase inhibitory activity of compounds 2, 4 and 7 and the antiplasmodial activity of compound 5 against P. falciparum strains TM4/8.2 and K1CB1 (multidrug resistant strain) are reported here for the first time. Stylopine (4) did not show antimalarial activity against the K1CB1 strain in contrast to a previous report. This study generated a scientific basis for the use of this plant in Bhutanese traditional medicine, either individually or in combination with other medicinal ingredients to treat a broad range of disorders. This study also identified compound 5 as potential new antimalarial lead compound.

Subject(s)

13 oxocryptopine
 13 oxoprotopine
 Amoxicillin
 Amphotericin B
 Antibiotic agent
 Antiflagellate agent
 Antifungal agent
 Antiinflammatory agent
 Antimalarial agent
 Antitrypanosomal agent
 Bicuculline
 Chloroquine
 Coreximine
 Corydalis crispa extract
 Cycloguanil
 Dexamethasone
 Galantamine
 Ochrobirine
 Pb 113
 Plant extract
 Plant medicinal product
 Protopine
 Pyrimethamine
 Rheagenine
 Sibiricine
 Stylopine
 Unclassified drug
 Vancomycin
 Antibacterial activity
 Antifungal activity
 Antiinflammatory activity
 Antiprotozoal activity
 Article
 Bhutan
 Biological activity
 Controlled study
 Corydalis crispa
 Cytokine production
 Drug isolation
 Drug mechanism
 Drug screening
 Drug structure
 Enzyme inhibition
 Nonhuman
 Nuclear magnetic resonance
 Papaveraceae
 Phytochemistry
 Plasmodium falciparum
 Corydalis
 Fumariaceae
 Plasmodium falciparum

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URI

https://hdl.handle.net/20.500.14740/7070

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Scopus: Year 1983-2021

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