Formulation of monomyristin-loaded polyester nanoparticles with controlled surface properties

Abstract

Monomyristin (MM), a monoacylglycerol with very low water solubility, has been reported to exhibit anti-proliferative property against cervical cancer cells. In order to increase its bioavailability, MM was encapsulated for the first time inside dextran-covered poly(lactic acid) nanoparticles. The use of dextran-based stabilizers with convenient structural characteristics was shown to provide important end-use properties to particle suspensions like colloidal stability during extensive washing steps or in the presence of high ionic strengths, easy reconstitution after lyophilization without particle aggregation in the absence of added cryoprotectant. Furthermore, immobilization of proteins at the surface of loaded particles was investigated with Bovine Serum Albumin and Transferrin using functionalized dextran-based stabilizers. The nature of links (covalent or non-covalent) between proteins and dextran-based superficial layer was discussed. © 2020 Elsevier B.V.