Publication:
Formulation of monomyristin-loaded polyester nanoparticles with controlled surface properties

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Issued Date

2020

Resource Type

Article

File Type

application/pdf

ISSN

9277757

DOI

10.1016/j.colsurfa.2020.124616

Other identifier(s)

2-s2.0-85080057111

Rights Holder(s)

Scopus

Bibliographic Citation

Colloids and Surfaces A: Physicochemical and Engineering Aspects. Vol 593, (2020)

Suggested Citation

Boondireke S., Liu C., T. Wongsatayanon B., Léonard M., Durand A. Formulation of monomyristin-loaded polyester nanoparticles with controlled surface properties. Colloids and Surfaces A: Physicochemical and Engineering Aspects. Vol 593, (2020). doi:10.1016/j.colsurfa.2020.124616 Retrieved from: https://hdl.handle.net/20.500.14740/4552

Title

Formulation of monomyristin-loaded polyester nanoparticles with controlled surface properties

Author(s)

Boondireke S.
 Liu C.
 T. Wongsatayanon B.
 Léonard M.
 Durand A.

Abstract

Monomyristin (MM), a monoacylglycerol with very low water solubility, has been reported to exhibit anti-proliferative property against cervical cancer cells. In order to increase its bioavailability, MM was encapsulated for the first time inside dextran-covered poly(lactic acid) nanoparticles. The use of dextran-based stabilizers with convenient structural characteristics was shown to provide important end-use properties to particle suspensions like colloidal stability during extensive washing steps or in the presence of high ionic strengths, easy reconstitution after lyophilization without particle aggregation in the absence of added cryoprotectant. Furthermore, immobilization of proteins at the surface of loaded particles was investigated with Bovine Serum Albumin and Transferrin using functionalized dextran-based stabilizers. The nature of links (covalent or non-covalent) between proteins and dextran-based superficial layer was discussed. © 2020 Elsevier B.V.

Subject(s)

Agglomeration
 Biochemistry
 Dextran
 Encapsulation
 Ionic strength
 Lactic acid
 Mammals
 Nanoparticles
 Proteins
 Sols
 Bovine serum albumins
 Functionalized dextrans
 Hydrophobically modified dextran
 Monomyristin
 Poly lactic acid
 Polyester nanoparticles
 Structural characteristics
 Transferrin
 Suspensions (fluids)
 Bovine serum albumin
 Dextran
 Monoacylglycerol
 Monomyristin
 Nanoparticle
 Polyester
 Polylactic acid
 Stabilizing agent
 Transferrin
 Unclassified drug
 Article
 Colloid
 Controlled study
 Covalent bond
 Drug formulation
 Drug solubility
 Freeze drying
 Ionic strength
 Nanoencapsulation
 Priority journal
 Surface property
 Suspension

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URI

https://hdl.handle.net/20.500.14740/4552

Collections

Scopus: Year 1983-2021

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