Publication:
Cytotoxic activities of trichothecenes isolated from an endophytic fungus belonging to order hypocreales

Simple item page
dc.contributor.authorChinworrungsee M.
dc.contributor.authorWiyakrutta S.
dc.contributor.authorSriubolmas N.
dc.contributor.authorChuailua P.
dc.contributor.authorSuksamrarn A.
dc.date.accessioned2021-04-05T04:32:00Z
dc.date.available2021-04-05T04:32:00Z
dc.date.issued2008
dc.date.issuedBE2551
dc.description.abstractBioassay-guided fractionation of the extract of the endophytic fungus KLAR 5 belonging to order Hypocreales, which was isolated from the twig of Knema laurina (Blume) Warb., resulted in the isolation of brefeldin A (1), 8-deoxy-trichothecin (2), trichothecolone (3), 7α-hydroxytrichodermol (4), and 7α-hydroxyscirpene (5). Compound 5 was isolated from natural source for the first time. Compound 1 was very highly active against human epidermoid carcinoma of the mouth, human breast cancer (BC-1), and human small cell lung cancer (NCI-H187) cells whereas compounds 2 and 4 were selectively active against BC-1 and NCI-H187 cells. Compounds 3 and 5 were moderately active against these three cancer cell lines. © 2008 The Pharmaceutical Society of Korea.
dc.format.mimetypeapplication/pdf
dc.identifier.citationArchives of Pharmacal Research. Vol 31, No.5 (2008), p.611-616
dc.identifier.doi10.1007/s12272-001-1201-x
dc.identifier.issn2536269
dc.identifier.other2-s2.0-43749109407
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4039
dc.rights.holderScopus
dc.subject.otherAntineoplastic agent
dc.subject.otherTrichothecene derivative
dc.subject.otherArticle
dc.subject.otherAscomycetes
dc.subject.otherDrug screening
dc.subject.otherHuman
dc.subject.otherIsolation and purification
dc.subject.otherMicrobiology
dc.subject.otherMyristicaceae
dc.subject.otherTumor cell line
dc.subject.otherAntineoplastic Agents
dc.subject.otherCell Line, Tumor
dc.subject.otherDrug Screening Assays, Antitumor
dc.subject.otherHumans
dc.subject.otherHypocreales
dc.subject.otherMyristicaceae
dc.subject.otherTrichothecenes
dc.titleCytotoxic activities of trichothecenes isolated from an endophytic fungus belonging to order hypocreales
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-43749109407&doi=10.1007%2fs12272-001-1201-x&partnerID=40&md5=f3eeae33e0408809ac9c80ac45eb3e2e

Files

Collections

Scopus: Year 1983-2021