Publication: Cytotoxic activities of trichothecenes isolated from an endophytic fungus belonging to order hypocreales
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Issued Date
2008
Resource Type
File Type
application/pdf
ISSN
2536269
Other identifier(s)
2-s2.0-43749109407
Rights Holder(s)
Scopus
Bibliographic Citation
Archives of Pharmacal Research. Vol 31, No.5 (2008), p.611-616
Suggested Citation
Chinworrungsee M., Wiyakrutta S., Sriubolmas N., Chuailua P., Suksamrarn A. Cytotoxic activities of trichothecenes isolated from an endophytic fungus belonging to order hypocreales. Archives of Pharmacal Research. Vol 31, No.5 (2008), p.611-616. doi:10.1007/s12272-001-1201-x Retrieved from: https://hdl.handle.net/20.500.14740/4039
Abstract
Bioassay-guided fractionation of the extract of the endophytic fungus KLAR 5 belonging to order Hypocreales, which was isolated from the twig of Knema laurina (Blume) Warb., resulted in the isolation of brefeldin A (1), 8-deoxy-trichothecin (2), trichothecolone (3), 7α-hydroxytrichodermol (4), and 7α-hydroxyscirpene (5). Compound 5 was isolated from natural source for the first time. Compound 1 was very highly active against human epidermoid carcinoma of the mouth, human breast cancer (BC-1), and human small cell lung cancer (NCI-H187) cells whereas compounds 2 and 4 were selectively active against BC-1 and NCI-H187 cells. Compounds 3 and 5 were moderately active against these three cancer cell lines. © 2008 The Pharmaceutical Society of Korea.