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Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile

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dc.contributor.authorWangchuk P.
dc.contributor.authorPyne S.G.
dc.contributor.authorKeller P.A.
dc.contributor.authorItaweechotipatr M.
dc.contributor.authorKamchonwongpaisan S.
dc.date.accessioned2021-04-05T03:32:52Z
dc.date.available2021-04-05T03:32:52Z
dc.date.issued2014
dc.date.issuedBE2557
dc.description.abstractWith the objective of determining safety and verifying the traditional uses of the Bhutanese medicinal plant, Pleurospermum amabile Craib & W. W. Smith, we investigated its crude extracts and the isolated phytochemicals for their biological activities. Four phenylpropanoids [(E)-isomyristicin (1), (E)-isoapiol (2 ), methyl eugenol (3) and (E)-isoelemicin (4)] and six furanocoumarins [psoralen (5), bergapten (6), isoimperatorin (7), isopimpinellin (8 ), oxypeucedanin hydrate (9) and oxypeucedanin methanolate (10 )] were isolated from this plant. Among the test samples, compound 10 showed weak antibacterial activity against Bacillus subtilis and best antimalarial activity against the Plasmodium falciparum strains, TM4/8.2 (chloroquine and antifolate sensitive) and K1CB1 (multidrug resistant). None of the test samples showed cytotoxicity. This study generated scientific data that support the traditional medical uses of the plant.
dc.format.mimetypeapplication/pdf
dc.identifier.citationNatural Product Communications. Vol 9, No.7 (2014), p.957-960
dc.identifier.doi10.1177/1934578x1400900719
dc.identifier.issn1934578X
dc.identifier.other2-s2.0-84905105669
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6597
dc.rights.holderScopus
dc.subject.otherBergapten
dc.subject.otherCycloguanil
dc.subject.otherElemicin
dc.subject.otherEugenol
dc.subject.otherFolic acid antagonist
dc.subject.otherFurocoumarin derivative
dc.subject.otherIsoapiol
dc.subject.otherIsopimpinellin
dc.subject.otherMyristicin
dc.subject.otherOxypeucedanin
dc.subject.otherPhenyl group
dc.subject.otherPhenylpropanoid derivative
dc.subject.otherPlant extract
dc.subject.otherPleurospermum amabile extract
dc.subject.otherPsoralen
dc.subject.otherPyrimethamine
dc.subject.otherUnclassified drug
dc.subject.otherAnimal cell
dc.subject.otherAntibacterial activity
dc.subject.otherAntimalarial activity
dc.subject.otherArticle
dc.subject.otherBacillus subtilis
dc.subject.otherBhutan
dc.subject.otherControlled study
dc.subject.otherDrug isolation
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherMedicinal plant
dc.subject.otherNonhuman
dc.subject.otherPhytochemistry
dc.subject.otherPlasmodium
dc.subject.otherPleurospermum amabile
dc.subject.otherAnimals
dc.subject.otherAnti-Bacterial Agents
dc.subject.otherAntifungal Agents
dc.subject.otherAntimalarials
dc.subject.otherApiaceae
dc.subject.otherBacteria
dc.subject.otherBhutan
dc.subject.otherCandida
dc.subject.otherCercopithecus aethiops
dc.subject.otherMolecular Structure
dc.subject.otherPlants, Medicinal
dc.subject.otherPlasmodium falciparum
dc.subject.otherPropanols
dc.subject.otherPsoralens
dc.subject.otherVero Cells
dc.titlePhenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84905105669&doi=10.1177%2f1934578x1400900719&partnerID=40&md5=c221e6ea9a07d1da5207bbc4dc70610c

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