Publication:
Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile

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Issued Date

2014

Resource Type

Article

File Type

application/pdf

ISSN

1934578X

DOI

10.1177/1934578x1400900719

Other identifier(s)

2-s2.0-84905105669

Rights Holder(s)

Scopus

Bibliographic Citation

Natural Product Communications. Vol 9, No.7 (2014), p.957-960

Suggested Citation

Wangchuk P., Pyne S.G., Keller P.A., Itaweechotipatr M., Kamchonwongpaisan S. Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile. Natural Product Communications. Vol 9, No.7 (2014), p.957-960. doi:10.1177/1934578x1400900719 Retrieved from: https://hdl.handle.net/20.500.14740/6597

Title

Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile

Author(s)

Wangchuk P.
 Pyne S.G.
 Keller P.A.
 Itaweechotipatr M.
 Kamchonwongpaisan S.

Abstract

With the objective of determining safety and verifying the traditional uses of the Bhutanese medicinal plant, Pleurospermum amabile Craib & W. W. Smith, we investigated its crude extracts and the isolated phytochemicals for their biological activities. Four phenylpropanoids [(E)-isomyristicin (1), (E)-isoapiol (2 ), methyl eugenol (3) and (E)-isoelemicin (4)] and six furanocoumarins [psoralen (5), bergapten (6), isoimperatorin (7), isopimpinellin (8 ), oxypeucedanin hydrate (9) and oxypeucedanin methanolate (10 )] were isolated from this plant. Among the test samples, compound 10 showed weak antibacterial activity against Bacillus subtilis and best antimalarial activity against the Plasmodium falciparum strains, TM4/8.2 (chloroquine and antifolate sensitive) and K1CB1 (multidrug resistant). None of the test samples showed cytotoxicity. This study generated scientific data that support the traditional medical uses of the plant.

Subject(s)

Bergapten
 Cycloguanil
 Elemicin
 Eugenol
 Folic acid antagonist
 Furocoumarin derivative
 Isoapiol
 Isopimpinellin
 Myristicin
 Oxypeucedanin
 Phenyl group
 Phenylpropanoid derivative
 Plant extract
 Pleurospermum amabile extract
 Psoralen
 Pyrimethamine
 Unclassified drug
 Animal cell
 Antibacterial activity
 Antimalarial activity
 Article
 Bacillus subtilis
 Bhutan
 Controlled study
 Drug isolation
 Human
 Human cell
 Medicinal plant
 Nonhuman
 Phytochemistry
 Plasmodium
 Pleurospermum amabile
 Animals
 Anti-Bacterial Agents
 Antifungal Agents
 Antimalarials
 Apiaceae
 Bacteria
 Bhutan
 Candida
 Cercopithecus aethiops
 Molecular Structure
 Plants, Medicinal
 Plasmodium falciparum
 Propanols
 Psoralens
 Vero Cells

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URI

https://hdl.handle.net/20.500.14740/6597

Collections

Scopus: Year 1983-2021

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