Publication:
Iridoids with anti-inflammatory activity from Vitex peduncularis

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Issued Date

2002

Resource Type

Article

File Type

application/pdf

ISSN

320943

DOI

10.1055/s-2002-20048

Other identifier(s)

2-s2.0-0036154975

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Planta Medica. Vol 68, No.1 (2002), p.72-73

Suggested Citation

Suksamrarn A., Kumpun S., Kirtikara K., Yingyongnarongkul B., Suksamrarn S. Iridoids with anti-inflammatory activity from Vitex peduncularis. Planta Medica. Vol 68, No.1 (2002), p.72-73. doi:10.1055/s-2002-20048 Retrieved from: https://hdl.handle.net/20.500.14740/6738

Title

Iridoids with anti-inflammatory activity from Vitex peduncularis

Author(s)

Suksamrarn A.
 Kumpun S.
 Kirtikara K.
 Yingyongnarongkul B.
 Suksamrarn S.

Abstract

A new iridoid, pedunculariside, together with the known iridoid agnuside were isolated from the butanol extract of Vitex peduncularis stem bark. Both pedunculariside and agnuside showed preferential inhibition of COX-2, with IC50 values of 0.15 ± 0.21 mg/ml and 0.026 ± 0.015 mg/ml respectively, while having only small inhibitory effects on COX-1. Both compounds did not exhibit cytotoxicity against vero cells.

Subject(s)

Agnuside
 Antiinflammatory agent
 Cyclooxygenase 2
 Iridoid
 Pedunculariside
 Plant extract
 Unclassified drug
 Vitex peduncularis extract
 Animal cell
 Antiinflammatory activity
 Article
 Bark
 Controlled study
 Cytotoxicity
 Drug isolation
 Drug structure
 Enzyme inhibition
 IC 50
 Nonhuman
 Vero cell
 Animals
 Anti-Inflammatory Agents
 Cercopithecus aethiops
 Cyclooxygenase 1
 Cyclooxygenase 2
 Glucosides
 Iridoids
 Isoenzymes
 Magnetic Resonance Spectroscopy
 Membrane Proteins
 Mice
 Plant Extracts
 Prostaglandin-Endoperoxide Synthases
 Pyrans
 Vero Cells
 Vitex
 Animalia
 Vitex

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URI

https://hdl.handle.net/20.500.14740/6738

Collections

Scopus: Year 1983-2021

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