Publication:
Highly oxygenated antiausterity agents from the leaves of Uvaria dac

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dc.contributor.authorAwale S.
dc.contributor.authorTawila A.M.
dc.contributor.authorDibwe D.F.
dc.contributor.authorUeda J.-Y.
dc.contributor.authorSun S.
dc.contributor.authorAthikomkulchai S.
dc.contributor.authorBalachandran C.
dc.contributor.authorSaiki I.
dc.contributor.authorMatsumoto K.
dc.contributor.authorEsumi H.
dc.date.accessioned2021-04-05T03:23:09Z
dc.date.available2021-04-05T03:23:09Z
dc.date.issued2017
dc.date.issuedBE2560
dc.description.abstractFrom the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM). © 2017 Elsevier Ltd
dc.format.mimetypeapplication/pdf
dc.identifier.citationBioorganic and Medicinal Chemistry Letters. Vol 27, No.9 (2017), p.1967-1971
dc.identifier.doi10.1016/j.bmcl.2017.03.021
dc.identifier.issn0960894X
dc.identifier.other2-s2.0-85015942234
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4798
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherAntineoplastic agent
dc.subject.otherCyclohexene derivative
dc.subject.otherUnclassified drug
dc.subject.otherUvaridacol i
dc.subject.otherUvaridacol j
dc.subject.otherUvaridacol k
dc.subject.otherUvaridacol l
dc.subject.otherAntineoplastic agent
dc.subject.otherCyclohexene
dc.subject.otherCyclohexene derivative
dc.subject.otherOxygen
dc.subject.otherArticle
dc.subject.otherCapan 1 cell line
dc.subject.otherCarbon nuclear magnetic resonance
dc.subject.otherCircular dichroism
dc.subject.otherCytotoxicity
dc.subject.otherDrug potency
dc.subject.otherHeteronuclear multiple bond correlation
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherKLM 1 cell line
dc.subject.otherNuclear magnetic resonance spectroscopy
dc.subject.otherNuclear Overhauser effect
dc.subject.otherPaCa 2 cell line
dc.subject.otherPANC 1 cell line
dc.subject.otherPancreatic cancer cell line
dc.subject.otherPlant leaf
dc.subject.otherProton nuclear magnetic resonance
dc.subject.otherPSN 1 cell line
dc.subject.otherUvaria
dc.subject.otherUvaria dac
dc.subject.otherChemistry
dc.subject.otherDrug effects
dc.subject.otherDrug screening
dc.subject.otherIsolation and purification
dc.subject.otherPancreas
dc.subject.otherPancreatic Neoplasms
dc.subject.otherPlant leaf
dc.subject.otherTumor cell line
dc.subject.otherUvaria
dc.subject.otherAntineoplastic Agents, Phytogenic
dc.subject.otherCell Line, Tumor
dc.subject.otherCyclohexenes
dc.subject.otherDrug Screening Assays, Antitumor
dc.subject.otherHumans
dc.subject.otherOxygen
dc.subject.otherPancreas
dc.subject.otherPancreatic Neoplasms
dc.subject.otherPlant Leaves
dc.subject.otherUvaria
dc.titleHighly oxygenated antiausterity agents from the leaves of Uvaria dac
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85015942234&doi=10.1016%2fj.bmcl.2017.03.021&partnerID=40&md5=5984c6328985a72cbb5aeb226472c166

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