Publication:
Highly oxygenated antiausterity agents from the leaves of Uvaria dac

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

0960894X

DOI

10.1016/j.bmcl.2017.03.021

Other identifier(s)

2-s2.0-85015942234

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Bioorganic and Medicinal Chemistry Letters. Vol 27, No.9 (2017), p.1967-1971

Suggested Citation

Awale S., Tawila A.M., Dibwe D.F., Ueda J.-Y., Sun S., Athikomkulchai S., Balachandran C., Saiki I., Matsumoto K., Esumi H. Highly oxygenated antiausterity agents from the leaves of Uvaria dac. Bioorganic and Medicinal Chemistry Letters. Vol 27, No.9 (2017), p.1967-1971. doi:10.1016/j.bmcl.2017.03.021 Retrieved from: https://hdl.handle.net/20.500.14740/4798

Title

Highly oxygenated antiausterity agents from the leaves of Uvaria dac

Author(s)

Awale S.
 Tawila A.M.
 Dibwe D.F.
 Ueda J.-Y.
 Sun S.
 Athikomkulchai S.
 Balachandran C.
 Saiki I.
 Matsumoto K.
 Esumi H.

Abstract

From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM). © 2017 Elsevier Ltd

Subject(s)

Antineoplastic agent
 Cyclohexene derivative
 Unclassified drug
 Uvaridacol i
 Uvaridacol j
 Uvaridacol k
 Uvaridacol l
 Antineoplastic agent
 Cyclohexene
 Cyclohexene derivative
 Oxygen
 Article
 Capan 1 cell line
 Carbon nuclear magnetic resonance
 Circular dichroism
 Cytotoxicity
 Drug potency
 Heteronuclear multiple bond correlation
 Human
 Human cell
 KLM 1 cell line
 Nuclear magnetic resonance spectroscopy
 Nuclear Overhauser effect
 PaCa 2 cell line
 PANC 1 cell line
 Pancreatic cancer cell line
 Plant leaf
 Proton nuclear magnetic resonance
 PSN 1 cell line
 Uvaria
 Uvaria dac
 Chemistry
 Drug effects
 Drug screening
 Isolation and purification
 Pancreas
 Pancreatic Neoplasms
 Plant leaf
 Tumor cell line
 Uvaria
 Antineoplastic Agents, Phytogenic
 Cell Line, Tumor
 Cyclohexenes
 Drug Screening Assays, Antitumor
 Humans
 Oxygen
 Pancreas
 Pancreatic Neoplasms
 Plant Leaves
 Uvaria

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URI

https://hdl.handle.net/20.500.14740/4798

Collections

Scopus: Year 1983-2021

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