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Acute inhibitory effect of alpha-mangostin on sarcoplasmic reticulum calcium-ATPase and myocardial relaxation

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dc.contributor.authorPhungphong S.
dc.contributor.authorKijtawornrat A.
dc.contributor.authorDe Tombe P.P.
dc.contributor.authorWattanapermpool J.
dc.contributor.authorBupha-Intr T.
dc.contributor.authorSuksamrarn S.
dc.date.accessioned2021-04-05T03:22:01Z
dc.date.available2021-04-05T03:22:01Z
dc.date.issued2017
dc.date.issuedBE2560
dc.description.abstractThe benefits of α-mangostin for various tissues have been reported, but its effect on the heart has not been clarified. This study aimed to evaluate the effects of α-mangostin on cardiac function. Using a cardiac sarcoplasmic reticulum (SR) membrane preparation, α-mangostin inhibited SR Ca2+-ATPase activity in a dose-dependent manner (IC50 of 6.47 ± 0.7 μM). Its suppressive effect was specific to SR Ca2+-ATPase but not to myofibrillar Ca2+-ATPase. Using isolated cardiomyocytes, 50 μM of α-mangostin significantly increased the duration of cell relengthening and increased the duration of Ca2+ transient decay, suggesting altered myocyte relaxation. The relaxation effect of α-mangostin was also supported in vivo after intravenous infusion. A significant suppression of both peak pressure and rate of ventricular relaxation (–dP/dt) relative to DMSO infusion was observed. The results from the present study demonstrated that α-mangostin exerts specific inhibitory action on SR Ca2+-ATPase activity, leading to myocardial relaxation dysfunction. © 2017 Wiley Periodicals, Inc.
dc.format.mimetypeapplication/pdf
dc.identifier.citationJournal of Biochemical and Molecular Toxicology. Vol 31, No.10 (2017)
dc.identifier.doi10.1002/jbt.21942
dc.identifier.issn10956670
dc.identifier.other2-s2.0-85020256751
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4066
dc.rights.holderScopus
dc.subject.otherAdenosine triphosphatase (calcium)
dc.subject.otherAdenosine triphosphatase (magnesium)
dc.subject.otherAlpha mangostin
dc.subject.otherCalcium ion
dc.subject.otherDimethyl sulfoxide
dc.subject.otherSarcoplasmic reticulum calcium transporting adenosine triphosphatase
dc.subject.otherUnclassified drug
dc.subject.otherXanthone derivative
dc.subject.otherMangostin
dc.subject.otherSarcoplasmic reticulum calcium transporting adenosine triphosphatase
dc.subject.otherXanthone derivative
dc.subject.otherAdult
dc.subject.otherAnimal cell
dc.subject.otherAnimal experiment
dc.subject.otherAnimal tissue
dc.subject.otherArticle
dc.subject.otherCardiac muscle cell
dc.subject.otherCell isolation
dc.subject.otherConcentration response
dc.subject.otherDose response
dc.subject.otherDrug dose comparison
dc.subject.otherDrug specificity
dc.subject.otherEnzyme inhibition
dc.subject.otherHeart left ventricle pressure
dc.subject.otherHeart left ventricle relaxation
dc.subject.otherHeart muscle relaxation
dc.subject.otherIn vitro study
dc.subject.otherIn vivo study
dc.subject.otherMale
dc.subject.otherNonhuman
dc.subject.otherRat
dc.subject.otherAnimal
dc.subject.otherAntagonists and inhibitors
dc.subject.otherCardiac muscle
dc.subject.otherDiastole
dc.subject.otherDrug effects
dc.subject.otherHeart ventricle
dc.subject.otherLeporidae
dc.subject.otherMetabolism
dc.subject.otherPathophysiology
dc.subject.otherAnimals
dc.subject.otherDiastole
dc.subject.otherHeart Ventricles
dc.subject.otherMale
dc.subject.otherMyocardium
dc.subject.otherMyocytes, Cardiac
dc.subject.otherRabbits
dc.subject.otherSarcoplasmic Reticulum Calcium-Transporting ATPases
dc.subject.otherXanthones
dc.titleAcute inhibitory effect of alpha-mangostin on sarcoplasmic reticulum calcium-ATPase and myocardial relaxation
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85020256751&doi=10.1002%2fjbt.21942&partnerID=40&md5=09ca837c52a5416a4bc27861793e15e0

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