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Barakol suppresses norepinephrine-induced inhibition of spontaneous longitudinal smooth muscle contractions in isolated rat small intestine

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dc.contributor.authorDeachapunya C.
dc.contributor.authorThongsaard W.
dc.contributor.authorPoonyachoti S.
dc.date.accessioned2021-04-05T04:32:30Z
dc.date.available2021-04-05T04:32:30Z
dc.date.issued2005
dc.date.issuedBE2548
dc.description.abstractThe present study aimed to investigate the purgative effects of barakol, the purified extract of Cassia siamea Lam., on the longitudinal smooth muscle contractions of the rat ileum. The extract increased the force of spontaneous muscle contractions in a concentration-dependent manner (EC50 = 0.3 mM). Saxitoxin (0.3 μM) abolished the stimulatory effects of barakol, a result indicating a neural mechanism of action. In addition, atropine (10 μM) but not propanolol (10 μM) or phentolamine (10 μM), partially inhibited barakol-induced smooth muscle contractions suggesting that cholinergic nerves were involved. The motor effects of barakol were further examined in muscle strips treated with catecholamines to suppress spontaneous contractile activity and decrease muscle tone. Norepinephrine or dopamine (10 μM) decreased the amplitude of spontaneous contractions by 72% and 18%, respectively. Pretreatment of the tissues with barakol (1 mM) significantly decreased the inhibitory effect of norepinephrine by 60%, but not that of dopamine. Its ability to potentiate atropine- and saxitoxin-sensitive contractions and inhibit the antimotility actions of norepinephrine suggests that barakol may increase longitudinal smooth muscle contractions by decreasing the inhibitory effect of norepinephrine on excitatory cholinergic motor neurons. Barakol may produce a purgative action in small intestine which may be clinically important in patients with intestinal hypomotility disorders. © 2005 Elsevier Ireland Ltd. All rights reserved.
dc.format.mimetypeapplication/pdf
dc.identifier.citationJournal of Ethnopharmacology. Vol 101, (2005), p.227-232
dc.identifier.doi10.1016/j.jep.2005.04.017
dc.identifier.issn3788741
dc.identifier.other2-s2.0-24644524706
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6051
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherAtropine
dc.subject.otherBarakol
dc.subject.otherCassia extract
dc.subject.otherCatecholamine
dc.subject.otherDopamine
dc.subject.otherNoradrenalin
dc.subject.otherPhentolamine
dc.subject.otherPropranolol
dc.subject.otherSaxitoxin
dc.subject.otherUnclassified drug
dc.subject.otherAnimal tissue
dc.subject.otherArticle
dc.subject.otherCassia siamea
dc.subject.otherCholinergic nerve
dc.subject.otherConcentration response
dc.subject.otherDrug mechanism
dc.subject.otherIleum contraction
dc.subject.otherIntestine innervation
dc.subject.otherMale
dc.subject.otherMotoneuron
dc.subject.otherNonhuman
dc.subject.otherParasympathetic innervation
dc.subject.otherRat
dc.subject.otherSenna
dc.subject.otherSmooth muscle contraction
dc.subject.otherSmooth muscle tone
dc.subject.otherAnimals
dc.subject.otherBenzopyrans
dc.subject.otherDopamine
dc.subject.otherDose-Response Relationship, Drug
dc.subject.otherIleum
dc.subject.otherMale
dc.subject.otherMuscle Contraction
dc.subject.otherMuscle, Smooth
dc.subject.otherNorepinephrine
dc.subject.otherPhenalenes
dc.subject.otherRats
dc.subject.otherRats, Wistar
dc.subject.otherSenna siamea
dc.titleBarakol suppresses norepinephrine-induced inhibition of spontaneous longitudinal smooth muscle contractions in isolated rat small intestine
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-24644524706&doi=10.1016%2fj.jep.2005.04.017&partnerID=40&md5=36d3fd1417dfecc28b88431720b6a134

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