Publication:
Modified biomolecule as potential vehicle for buccal delivery of doxepin

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dc.contributor.authorLaffleur F.
dc.contributor.authorZilio M.
dc.contributor.authorShuwisitkul D.
dc.date.accessioned2021-04-05T03:23:30Z
dc.date.available2021-04-05T03:23:30Z
dc.date.issued2016
dc.date.issuedBE2559
dc.description.abstractAim: Doxepin is a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa. Doxepin is one approach in treating insomnia and depression in Parkinson's disease. Patients with Parkinson's disease suffer difficulties in swallowing. Therefore, it was the aim of this study to develop a buccal-adhesive delivery system. Methods: Pectin was modified with cysteine. Stability assays in form of disintegration assay according to the Ph.Eur were performed. Furthermore, bioadhesiveness on buccal mucosa was investigated incorporating the drug doxepin. Results: The adhesiveness was improved 1.4-fold and revealed a sustained release over 3 h. Conclusion: Taking these findings into account, the modifications render this designed excipient fruitful for buccal delivery. © 2016 Future Science Ltd.
dc.format.mimetypeapplication/pdf
dc.identifier.citationTherapeutic Delivery. Vol 7, No.10 (2016), p.683-689
dc.identifier.doi10.4155/tde-2016-0046
dc.identifier.issn20415990
dc.identifier.other2-s2.0-84994152086
dc.identifier.urihttps://hdl.handle.net/20.500.14740/5115
dc.rights.holderScopus
dc.subject.otherCysteine
dc.subject.otherDisulfide
dc.subject.otherDoxepin
dc.subject.otherPectin
dc.subject.otherDoxepin
dc.subject.otherDrug carrier
dc.subject.otherAnimal tissue
dc.subject.otherArticle
dc.subject.otherCell viability
dc.subject.otherCheek mucosa
dc.subject.otherComparative study
dc.subject.otherControlled study
dc.subject.otherDisulfide bond
dc.subject.otherDrug delivery system
dc.subject.otherGravimetry
dc.subject.otherInfrared spectroscopy
dc.subject.otherMucoadhesion
dc.subject.otherNonhuman
dc.subject.otherPH
dc.subject.otherPolymerization
dc.subject.otherPriority journal
dc.subject.otherResazurin assay
dc.subject.otherSurface property
dc.subject.otherSustained drug release
dc.subject.otherSynthesis
dc.subject.otherAdhesion
dc.subject.otherBuccal drug administration
dc.subject.otherCell culture
dc.subject.otherCell survival
dc.subject.otherChemistry
dc.subject.otherDrug effects
dc.subject.otherDrug release
dc.subject.otherDrug stability
dc.subject.otherHuman
dc.subject.otherMouth mucosa
dc.subject.otherAdhesiveness
dc.subject.otherAdministration, Buccal
dc.subject.otherCell Survival
dc.subject.otherCells, Cultured
dc.subject.otherCysteine
dc.subject.otherDoxepin
dc.subject.otherDrug Carriers
dc.subject.otherDrug Liberation
dc.subject.otherDrug Stability
dc.subject.otherHumans
dc.subject.otherMouth Mucosa
dc.subject.otherPectins
dc.titleModified biomolecule as potential vehicle for buccal delivery of doxepin
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84994152086&doi=10.4155%2ftde-2016-0046&partnerID=40&md5=91cb891f84d0ec1c5d23949d515caff7

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