Publication:
Modified biomolecule as potential vehicle for buccal delivery of doxepin

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Issued Date

2016

Resource Type

Article

File Type

application/pdf

ISSN

20415990

DOI

10.4155/tde-2016-0046

Other identifier(s)

2-s2.0-84994152086

Rights Holder(s)

Scopus

Bibliographic Citation

Therapeutic Delivery. Vol 7, No.10 (2016), p.683-689

Suggested Citation

Laffleur F., Zilio M., Shuwisitkul D. Modified biomolecule as potential vehicle for buccal delivery of doxepin. Therapeutic Delivery. Vol 7, No.10 (2016), p.683-689. doi:10.4155/tde-2016-0046 Retrieved from: https://hdl.handle.net/20.500.14740/5115

Title

Modified biomolecule as potential vehicle for buccal delivery of doxepin

Author(s)

Laffleur F.
 Zilio M.
 Shuwisitkul D.

Abstract

Aim: Doxepin is a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa. Doxepin is one approach in treating insomnia and depression in Parkinson's disease. Patients with Parkinson's disease suffer difficulties in swallowing. Therefore, it was the aim of this study to develop a buccal-adhesive delivery system. Methods: Pectin was modified with cysteine. Stability assays in form of disintegration assay according to the Ph.Eur were performed. Furthermore, bioadhesiveness on buccal mucosa was investigated incorporating the drug doxepin. Results: The adhesiveness was improved 1.4-fold and revealed a sustained release over 3 h. Conclusion: Taking these findings into account, the modifications render this designed excipient fruitful for buccal delivery. © 2016 Future Science Ltd.

Subject(s)

Cysteine
 Disulfide
 Doxepin
 Pectin
 Doxepin
 Drug carrier
 Animal tissue
 Article
 Cell viability
 Cheek mucosa
 Comparative study
 Controlled study
 Disulfide bond
 Drug delivery system
 Gravimetry
 Infrared spectroscopy
 Mucoadhesion
 Nonhuman
 PH
 Polymerization
 Priority journal
 Resazurin assay
 Surface property
 Sustained drug release
 Synthesis
 Adhesion
 Buccal drug administration
 Cell culture
 Cell survival
 Chemistry
 Drug effects
 Drug release
 Drug stability
 Human
 Mouth mucosa
 Adhesiveness
 Administration, Buccal
 Cell Survival
 Cells, Cultured
 Cysteine
 Doxepin
 Drug Carriers
 Drug Liberation
 Drug Stability
 Humans
 Mouth Mucosa
 Pectins

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URI

https://hdl.handle.net/20.500.14740/5115

Collections

Scopus: Year 1983-2021

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