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Application of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols

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dc.contributor.authorSoponpong J.
dc.contributor.authorDolsophon K.
dc.contributor.authorThongpanchang C.
dc.contributor.authorLinden A.
dc.contributor.authorThongpanchang T.
dc.date.accessioned2021-04-05T03:03:43Z
dc.date.available2021-04-05T03:03:43Z
dc.date.issued2019
dc.date.issuedBE2562
dc.description.abstractThe structure of a constrained bicyclic chiral derivatizing agent (CDA), 1,2,3,4-tetrahydro-1,4-epoxynaphthalene-1-carboxylic acid, THENA 1, was modified by replacing both exo-methylene protons with deuterium atoms. The modified CDA, THENA-d 2 2, could be used to assign the absolute configuration of chiral secondary alcohols with good reliability. Compared with THENA, the multiplicity of the methylene proton signals in the 1 H NMR spectra of THENA-d 2 derivatives is less complicated and the new CDA thus offers simpler NMR spectra for data interpretation. © 2019 Elsevier Ltd
dc.format.mimetypeapplication/pdf
dc.identifier.citationTetrahedron Letters. Vol 60, No.6 (2019), p.497-500
dc.identifier.doi10.1016/j.tetlet.2019.01.013
dc.identifier.issn404039
dc.identifier.other2-s2.0-85059805363
dc.identifier.urihttps://hdl.handle.net/20.500.14740/5463
dc.rights.holderScopus
dc.subject.other1,2,3,4 tetrahydro 1,4 epoxynaphthalene 1 carboxylic acid
dc.subject.otherCarboxylic acid derivative
dc.subject.otherReagent
dc.subject.otherUnclassified drug
dc.subject.otherArticle
dc.subject.otherChiral chromatography
dc.subject.otherChirality
dc.subject.otherCrystal structure
dc.subject.otherDerivatization
dc.subject.otherProton nuclear magnetic resonance
dc.subject.otherReaction analysis
dc.subject.otherSynthesis
dc.subject.otherX ray diffraction
dc.titleApplication of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059805363&doi=10.1016%2fj.tetlet.2019.01.013&partnerID=40&md5=0218c68347ee364cccd5d50634cd65d9

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