Publication:
Application of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols

0
0

Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

404039

DOI

10.1016/j.tetlet.2019.01.013

Other identifier(s)

2-s2.0-85059805363

Rights Holder(s)

Scopus

Bibliographic Citation

Tetrahedron Letters. Vol 60, No.6 (2019), p.497-500

Suggested Citation

Soponpong J., Dolsophon K., Thongpanchang C., Linden A., Thongpanchang T. Application of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols. Tetrahedron Letters. Vol 60, No.6 (2019), p.497-500. doi:10.1016/j.tetlet.2019.01.013 Retrieved from: https://hdl.handle.net/20.500.14740/5463

Title

Application of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols

Author(s)

Soponpong J.
 Dolsophon K.
 Thongpanchang C.
 Linden A.
 Thongpanchang T.

Abstract

The structure of a constrained bicyclic chiral derivatizing agent (CDA), 1,2,3,4-tetrahydro-1,4-epoxynaphthalene-1-carboxylic acid, THENA 1, was modified by replacing both exo-methylene protons with deuterium atoms. The modified CDA, THENA-d 2 2, could be used to assign the absolute configuration of chiral secondary alcohols with good reliability. Compared with THENA, the multiplicity of the methylene proton signals in the 1 H NMR spectra of THENA-d 2 derivatives is less complicated and the new CDA thus offers simpler NMR spectra for data interpretation. © 2019 Elsevier Ltd

Subject(s)

1,2,3,4 tetrahydro 1,4 epoxynaphthalene 1 carboxylic acid
 Carboxylic acid derivative
 Reagent
 Unclassified drug
 Article
 Chiral chromatography
 Chirality
 Crystal structure
 Derivatization
 Proton nuclear magnetic resonance
 Reaction analysis
 Synthesis
 X ray diffraction

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/5463

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By