Publication:
Hyaluronic acid graft polymers displaying peptide antigen modulate dendritic cell response in vitro

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dc.contributor.authorChittasupho C.
dc.contributor.authorSestak J.
dc.contributor.authorShannon L.
dc.contributor.authorSiahaan T.J.
dc.contributor.authorVines C.M.
dc.contributor.authorBerkland C.
dc.date.accessioned2021-04-05T03:35:12Z
dc.date.available2021-04-05T03:35:12Z
dc.date.issued2014
dc.date.issuedBE2557
dc.description.abstractA novel oxime grafting scheme was utilized to conjugate an ICAM-1 ligand (LABL), a cellular antigen ovalbumin (OVA), or both peptides simultaneously to hyaluronic acid (HA). Samples of HA only and the various peptide grafted HA were found to bind to dendritic cells (DCs). HA with grafted LABL and OVA showed the greatest binding to DCs. Dendritic cells treated with HA, HA with grafted LABL, or HA with grafted LABL and OVA significantly suppressed T cell and DC conjugate formation and T cell proliferation and reduced proinflammatory cytokine production compared to untreated cells. These results suggest that HA serves as an effective backbone for multivalent ligand presentation for inhibiting T cell response to antigen presentation. In addition, multivalent display of both antigen and an ICAM-1 inhibitor (LABL) may enhance binding to DCs and could potentially disrupt cellular signaling leading to autoimmunity. © 2013 American Chemical Society.
dc.format.mimetypeapplication/pdf
dc.identifier.citationMolecular Pharmaceutics. Vol 11, No.1 (2014), p.367-373
dc.identifier.doi10.1021/mp4003909
dc.identifier.issn15438384
dc.identifier.other2-s2.0-84891756544
dc.identifier.urihttps://hdl.handle.net/20.500.14740/7290
dc.rights.holderScopus
dc.subject.otherGamma interferon
dc.subject.otherHyaluronic acid
dc.subject.otherIntercellular adhesion molecule 1
dc.subject.otherInterleukin 10
dc.subject.otherInterleukin 17
dc.subject.otherInterleukin 4
dc.subject.otherOvalbumin
dc.subject.otherPolymer
dc.subject.otherTumor necrosis factor alpha
dc.subject.otherAnimal cell
dc.subject.otherAnimal experiment
dc.subject.otherAntigen presentation
dc.subject.otherArticle
dc.subject.otherCell adhesion
dc.subject.otherCell culture
dc.subject.otherCell surface
dc.subject.otherConjugation
dc.subject.otherControlled study
dc.subject.otherCytokine production
dc.subject.otherDendritic cell
dc.subject.otherFluorescence microscopy
dc.subject.otherImmune response
dc.subject.otherIn vitro study
dc.subject.otherLymphocyte proliferation
dc.subject.otherMacrophage
dc.subject.otherMouse
dc.subject.otherNeutrophil
dc.subject.otherNonhuman
dc.subject.otherPeptide synthesis
dc.subject.otherPriority journal
dc.subject.otherProtein binding
dc.subject.otherT lymphocyte
dc.subject.otherAnimals
dc.subject.otherAntigen-Presenting Cells
dc.subject.otherCD8-Positive T-Lymphocytes
dc.subject.otherCells, Cultured
dc.subject.otherCytokines
dc.subject.otherDendritic Cells
dc.subject.otherEnzyme-Linked Immunosorbent Assay
dc.subject.otherHyaluronic Acid
dc.subject.otherIntercellular Adhesion Molecule-1
dc.subject.otherLymphocyte Activation
dc.subject.otherMice
dc.subject.otherMice, Inbred C57BL
dc.subject.otherOvalbumin
dc.subject.otherPeptide Fragments
dc.subject.otherPolymers
dc.subject.otherT-Lymphocytes, Regulatory
dc.titleHyaluronic acid graft polymers displaying peptide antigen modulate dendritic cell response in vitro
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84891756544&doi=10.1021%2fmp4003909&partnerID=40&md5=75df0a33de86306173559d9484569faf

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