Publication:
Effect of 20-hydroxyecdysone on proteolytic regulation in skeletal muscle atrophy

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dc.contributor.authorHirunsai M.
dc.contributor.authorYimlamai T.
dc.contributor.authorSuksamrarn A.
dc.date.accessioned2021-04-05T03:23:23Z
dc.date.available2021-04-05T03:23:23Z
dc.date.issued2016
dc.date.issuedBE2559
dc.description.abstractBackground/Aim: 20-Hydroxyecdystone (20E) is an ecdysteroid hormone which controls molting and reproduction in arthropods. 20E also produces a variety of effects in vertebrates, including enhancing protein synthesis and skeletal muscle regeneration. The effect of 20E on disuse muscle atrophy has not been reported to date. This study examined the proteolytic regulation of 20E in tenotomized rat slow soleus and fast plantaris muscles. Materials and Methods: Male Wistar rats were randomly divided into three groups: sedentary control (CON), tenotomy without 20E treatment (TEN), and tenotomy with treatment of 5 mg/kg BW of 20E (TEN+20E). The TEN+20E group was administered 20E via subcutaneous injection to the right thigh for 7 days after tenotomy. Results: 20E treatment tended to attenuate disuse muscle atrophy and reduced ubiquitination only in soleus muscle. Conclusion: 20E treatment alleviates skeletal muscle atrophy partially mediated by ubiquitinate pathway, dependent on the muscle phenotype. © 2016, International Institute of Anticancer Research. All rights reserved.
dc.format.mimetypeapplication/pdf
dc.identifier.citationIn Vivo. Vol 30, No.6 (2016), p.869-877
dc.identifier.doi10.21873/invivo.11007
dc.identifier.issn0258851X
dc.identifier.other2-s2.0-84994246675
dc.identifier.urihttps://hdl.handle.net/20.500.14740/5036
dc.rights.holderScopus
dc.subject.otherEcdysterone
dc.subject.otherMuscle protein
dc.subject.otherMuscle RING finger 1 protein
dc.subject.otherEcdysterone
dc.subject.otherUbiquitinated protein
dc.subject.otherAchilles tendon
dc.subject.otherAdult
dc.subject.otherAnimal experiment
dc.subject.otherAnimal model
dc.subject.otherAnimal tissue
dc.subject.otherArticle
dc.subject.otherBody weight
dc.subject.otherControlled study
dc.subject.otherHistology
dc.subject.otherMale
dc.subject.otherMuscle atrophy
dc.subject.otherMuscle mass
dc.subject.otherMuscle wet weight
dc.subject.otherNonhuman
dc.subject.otherPlantaris muscle
dc.subject.otherProtein degradation
dc.subject.otherProtein expression
dc.subject.otherRat
dc.subject.otherSkeletal muscle
dc.subject.otherSoleus muscle
dc.subject.otherTenotomy
dc.subject.otherUbiquitination
dc.subject.otherWestern blotting
dc.subject.otherAnimal
dc.subject.otherDrug effects
dc.subject.otherMetabolism
dc.subject.otherMuscle atrophy
dc.subject.otherPathology
dc.subject.otherProtein degradation
dc.subject.otherRandomization
dc.subject.otherSignal transduction
dc.subject.otherSkeletal muscle
dc.subject.otherSubcutaneous drug administration
dc.subject.otherWistar rat
dc.subject.otherAnimals
dc.subject.otherBlotting, Western
dc.subject.otherEcdysterone
dc.subject.otherInjections, Subcutaneous
dc.subject.otherMale
dc.subject.otherMuscle, Skeletal
dc.subject.otherMuscular Atrophy
dc.subject.otherProteolysis
dc.subject.otherRandom Allocation
dc.subject.otherRats, Wistar
dc.subject.otherSignal Transduction
dc.subject.otherTenotomy
dc.subject.otherUbiquitinated Proteins
dc.subject.otherUbiquitination
dc.titleEffect of 20-hydroxyecdysone on proteolytic regulation in skeletal muscle atrophy
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84994246675&doi=10.21873%2finvivo.11007&partnerID=40&md5=6a1b5fcb0dcc58301598696d69588ae3

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