Publication:
Effect of 20-hydroxyecdysone on proteolytic regulation in skeletal muscle atrophy

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Issued Date

2016

Resource Type

Article

File Type

application/pdf

ISSN

0258851X

DOI

10.21873/invivo.11007

Other identifier(s)

2-s2.0-84994246675

Rights Holder(s)

Scopus

Bibliographic Citation

In Vivo. Vol 30, No.6 (2016), p.869-877

Suggested Citation

Hirunsai M., Yimlamai T., Suksamrarn A. Effect of 20-hydroxyecdysone on proteolytic regulation in skeletal muscle atrophy. In Vivo. Vol 30, No.6 (2016), p.869-877. doi:10.21873/invivo.11007 Retrieved from: https://hdl.handle.net/20.500.14740/5036

Title

Effect of 20-hydroxyecdysone on proteolytic regulation in skeletal muscle atrophy

Author(s)

Hirunsai M.
 Yimlamai T.
 Suksamrarn A.

Abstract

Background/Aim: 20-Hydroxyecdystone (20E) is an ecdysteroid hormone which controls molting and reproduction in arthropods. 20E also produces a variety of effects in vertebrates, including enhancing protein synthesis and skeletal muscle regeneration. The effect of 20E on disuse muscle atrophy has not been reported to date. This study examined the proteolytic regulation of 20E in tenotomized rat slow soleus and fast plantaris muscles. Materials and Methods: Male Wistar rats were randomly divided into three groups: sedentary control (CON), tenotomy without 20E treatment (TEN), and tenotomy with treatment of 5 mg/kg BW of 20E (TEN+20E). The TEN+20E group was administered 20E via subcutaneous injection to the right thigh for 7 days after tenotomy. Results: 20E treatment tended to attenuate disuse muscle atrophy and reduced ubiquitination only in soleus muscle. Conclusion: 20E treatment alleviates skeletal muscle atrophy partially mediated by ubiquitinate pathway, dependent on the muscle phenotype. © 2016, International Institute of Anticancer Research. All rights reserved.

Subject(s)

Ecdysterone
 Muscle protein
 Muscle RING finger 1 protein
 Ecdysterone
 Ubiquitinated protein
 Achilles tendon
 Adult
 Animal experiment
 Animal model
 Animal tissue
 Article
 Body weight
 Controlled study
 Histology
 Male
 Muscle atrophy
 Muscle mass
 Muscle wet weight
 Nonhuman
 Plantaris muscle
 Protein degradation
 Protein expression
 Rat
 Skeletal muscle
 Soleus muscle
 Tenotomy
 Ubiquitination
 Western blotting
 Animal
 Drug effects
 Metabolism
 Muscle atrophy
 Pathology
 Protein degradation
 Randomization
 Signal transduction
 Skeletal muscle
 Subcutaneous drug administration
 Wistar rat
 Animals
 Blotting, Western
 Ecdysterone
 Injections, Subcutaneous
 Male
 Muscle, Skeletal
 Muscular Atrophy
 Proteolysis
 Random Allocation
 Rats, Wistar
 Signal Transduction
 Tenotomy
 Ubiquitinated Proteins
 Ubiquitination

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URI

https://hdl.handle.net/20.500.14740/5036

Collections

Scopus: Year 1983-2021

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