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Development of a gallic acid-loaded chitosan and polyvinyl alcohol hydrogel composite: Release characteristics and antioxidant activity

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dc.contributor.authorThanyacharoen T.
dc.contributor.authorChuysinuan P.
dc.contributor.authorTechasakul S.
dc.contributor.authorNooeaid P.
dc.contributor.authorUmmartyotin S.
dc.date.accessioned2021-04-05T03:21:38Z
dc.date.available2021-04-05T03:21:38Z
dc.date.issued2018
dc.date.issuedBE2561
dc.description.abstractThe physico-chemical properties of a chitosan and polyvinyl alcohol (CS/PVA)-based hydrogel composite were investigated. Tetraethyl orthosilicate (TEOS) was employed as a crosslinking agent. The results indicated that the chitosan-based composite presented a thermal resistance up to 200 °C. The structural properties, which were evaluated using FTIR and DSC, showed good miscibility between chitosan and polyvinyl alcohol. SEM presented a compact and homogeneous structure. The release profile of the chitosan-based hydrogel composite was investigated using gallic acid (GA). It showed high antioxidant activities, which were monitored using DPPH radical scavenging. Diffusion of water into the chitosan-based hydrogel was assumed to be pseudo-Fickian in PBS solution. The CS/PVA-based hydrogel composite exhibited good properties as a drug delivery system. © 2017 Elsevier B.V.
dc.format.mimetypeapplication/pdf
dc.identifier.citationInternational Journal of Biological Macromolecules. Vol 107, No.PartA (2018), p.363-370
dc.identifier.doi10.1016/j.ijbiomac.2017.09.002
dc.identifier.issn1418130
dc.identifier.other2-s2.0-85029565930
dc.identifier.urihttps://hdl.handle.net/20.500.14740/3713
dc.rights.holderScopus
dc.subject.otherChitosan
dc.subject.otherGallic acid
dc.subject.otherPolyvinyl alcohol
dc.subject.otherTetraethoxysilane
dc.subject.other1,1-diphenyl-2-picrylhydrazyl
dc.subject.otherAntioxidant
dc.subject.otherBiphenyl derivative
dc.subject.otherChitosan
dc.subject.otherGallic acid
dc.subject.otherPicric acid
dc.subject.otherPolyethylene glycol dimethacrylate hydrogel
dc.subject.otherPolyvinyl alcohol
dc.subject.otherPolyvinyl alcohol hydrogel
dc.subject.otherScavenger
dc.subject.otherAntioxidant activity
dc.subject.otherArticle
dc.subject.otherControlled study
dc.subject.otherDegradation
dc.subject.otherDifferential scanning calorimetry
dc.subject.otherDPPH radical scavenging assay
dc.subject.otherDrug delivery system
dc.subject.otherDrug release
dc.subject.otherDrug stability
dc.subject.otherEncapsulation
dc.subject.otherFourier transform infrared photoacoustic spectroscopy
dc.subject.otherHeat tolerance
dc.subject.otherHydrogel
dc.subject.otherMiscibility
dc.subject.otherPhysical chemistry
dc.subject.otherScanning electron microscopy
dc.subject.otherChemistry
dc.subject.otherInfrared spectroscopy
dc.subject.otherSynthesis
dc.subject.otherAntioxidants
dc.subject.otherBiphenyl Compounds
dc.subject.otherChitosan
dc.subject.otherDrug Delivery Systems
dc.subject.otherFree Radical Scavengers
dc.subject.otherGallic Acid
dc.subject.otherHydrogel, Polyethylene Glycol Dimethacrylate
dc.subject.otherPicrates
dc.subject.otherPolyvinyl Alcohol
dc.subject.otherSpectroscopy, Fourier Transform Infrared
dc.titleDevelopment of a gallic acid-loaded chitosan and polyvinyl alcohol hydrogel composite: Release characteristics and antioxidant activity
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85029565930&doi=10.1016%2fj.ijbiomac.2017.09.002&partnerID=40&md5=d9660695ce42d1ae6543e4ca838dd553

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