Publication:
Development of a gallic acid-loaded chitosan and polyvinyl alcohol hydrogel composite: Release characteristics and antioxidant activity

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Issued Date

2018

Resource Type

Article

File Type

application/pdf

ISSN

1418130

DOI

10.1016/j.ijbiomac.2017.09.002

Other identifier(s)

2-s2.0-85029565930

Rights Holder(s)

Scopus

Bibliographic Citation

International Journal of Biological Macromolecules. Vol 107, No.PartA (2018), p.363-370

Suggested Citation

Thanyacharoen T., Chuysinuan P., Techasakul S., Nooeaid P., Ummartyotin S. Development of a gallic acid-loaded chitosan and polyvinyl alcohol hydrogel composite: Release characteristics and antioxidant activity. International Journal of Biological Macromolecules. Vol 107, No.PartA (2018), p.363-370. doi:10.1016/j.ijbiomac.2017.09.002 Retrieved from: https://hdl.handle.net/20.500.14740/3713

Title

Development of a gallic acid-loaded chitosan and polyvinyl alcohol hydrogel composite: Release characteristics and antioxidant activity

Author(s)

Thanyacharoen T.
 Chuysinuan P.
 Techasakul S.
 Nooeaid P.
 Ummartyotin S.

Abstract

The physico-chemical properties of a chitosan and polyvinyl alcohol (CS/PVA)-based hydrogel composite were investigated. Tetraethyl orthosilicate (TEOS) was employed as a crosslinking agent. The results indicated that the chitosan-based composite presented a thermal resistance up to 200 °C. The structural properties, which were evaluated using FTIR and DSC, showed good miscibility between chitosan and polyvinyl alcohol. SEM presented a compact and homogeneous structure. The release profile of the chitosan-based hydrogel composite was investigated using gallic acid (GA). It showed high antioxidant activities, which were monitored using DPPH radical scavenging. Diffusion of water into the chitosan-based hydrogel was assumed to be pseudo-Fickian in PBS solution. The CS/PVA-based hydrogel composite exhibited good properties as a drug delivery system. © 2017 Elsevier B.V.

Subject(s)

Chitosan
 Gallic acid
 Polyvinyl alcohol
 Tetraethoxysilane
 1,1-diphenyl-2-picrylhydrazyl
 Antioxidant
 Biphenyl derivative
 Chitosan
 Gallic acid
 Picric acid
 Polyethylene glycol dimethacrylate hydrogel
 Polyvinyl alcohol
 Polyvinyl alcohol hydrogel
 Scavenger
 Antioxidant activity
 Article
 Controlled study
 Degradation
 Differential scanning calorimetry
 DPPH radical scavenging assay
 Drug delivery system
 Drug release
 Drug stability
 Encapsulation
 Fourier transform infrared photoacoustic spectroscopy
 Heat tolerance
 Hydrogel
 Miscibility
 Physical chemistry
 Scanning electron microscopy
 Chemistry
 Infrared spectroscopy
 Synthesis
 Antioxidants
 Biphenyl Compounds
 Chitosan
 Drug Delivery Systems
 Free Radical Scavengers
 Gallic Acid
 Hydrogel, Polyethylene Glycol Dimethacrylate
 Picrates
 Polyvinyl Alcohol
 Spectroscopy, Fourier Transform Infrared

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URI

https://hdl.handle.net/20.500.14740/3713

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Scopus: Year 1983-2021

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