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3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus

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dc.contributor.authorLawung R.
dc.contributor.authorTreeratanapiboon L.
dc.contributor.authorPrachayasittikul S.
dc.contributor.authorPrachayasittikul V.
dc.date.accessioned2021-04-05T03:36:18Z
dc.date.available2021-04-05T03:36:18Z
dc.date.issued2010
dc.date.issuedBE2553
dc.description.abstractIn a previous study, 5-(1-adamantylthio)-3-picoline (I) and 3-(1-adamantylthio)-4-phenylpyridine (II) were shown to have potent antimicrobial activity. The present investigation is concerned with the antimicrobial action of thiopyridines I and II against methicillin-resistant Staphylococcus aureus (MRSA) isolates and with their murine fibroblast (L929) cytotoxicity. Thiopyridine II was found to display significant antimicrobial activity against all of the MRSA isolates tested, with minimum inhibitory concentrations (MIC) of 1-8 μg/mL. Moreover, both I and II attenuate the viability of L929 cells in a dose-dependent manner, displaying an IC50 of 68.4±6.0 and 47.3±5.6 μg/mL, respectively. These findings suggest that thiopyridine II is promising as a lead compound for further development as a therapeutic. © 2010 Bentham Science Publishers Ltd.
dc.format.mimetypeapplication/pdf
dc.identifier.citationLetters in Drug Design and Discovery. Vol 7, No.9 (2010), p.674-678
dc.identifier.doi10.2174/157018010792929603
dc.identifier.issn15701808
dc.identifier.other2-s2.0-77958499309
dc.identifier.urihttps://hdl.handle.net/20.500.14740/7523
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.other3 (1 adamantylthio) 4 phenylpyridine
dc.subject.other5 (1 adamantylthio) 3 picoline
dc.subject.otherAntibiotic agent
dc.subject.otherPyridine derivative
dc.subject.otherUnclassified drug
dc.subject.otherAnimal cell
dc.subject.otherAntibacterial activity
dc.subject.otherArticle
dc.subject.otherCell viability
dc.subject.otherControlled study
dc.subject.otherCytotoxicity
dc.subject.otherDose response
dc.subject.otherFibroblast
dc.subject.otherIC 50
dc.subject.otherMethicillin resistant Staphylococcus aureus
dc.subject.otherMinimum inhibitory concentration
dc.subject.otherNonhuman
dc.subject.otherPriority journal
dc.title3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77958499309&doi=10.2174%2f157018010792929603&partnerID=40&md5=03dd7d646e3c50b31c359b7edba7555e

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