Publication: 3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus
0
0
Issued Date
2010
Resource Type
File Type
application/pdf
ISSN
15701808
Other identifier(s)
2-s2.0-77958499309
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Letters in Drug Design and Discovery. Vol 7, No.9 (2010), p.674-678
Suggested Citation
Lawung R., Treeratanapiboon L., Prachayasittikul S., Prachayasittikul V. 3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus. Letters in Drug Design and Discovery. Vol 7, No.9 (2010), p.674-678. doi:10.2174/157018010792929603 Retrieved from: https://hdl.handle.net/20.500.14740/7523
Abstract
In a previous study, 5-(1-adamantylthio)-3-picoline (I) and 3-(1-adamantylthio)-4-phenylpyridine (II) were shown to have potent antimicrobial activity. The present investigation is concerned with the antimicrobial action of thiopyridines I and II against methicillin-resistant Staphylococcus aureus (MRSA) isolates and with their murine fibroblast (L929) cytotoxicity. Thiopyridine II was found to display significant antimicrobial activity against all of the MRSA isolates tested, with minimum inhibitory concentrations (MIC) of 1-8 μg/mL. Moreover, both I and II attenuate the viability of L929 cells in a dose-dependent manner, displaying an IC50 of 68.4±6.0 and 47.3±5.6 μg/mL, respectively. These findings suggest that thiopyridine II is promising as a lead compound for further development as a therapeutic. © 2010 Bentham Science Publishers Ltd.
Subject(s)
3 (1 adamantylthio) 4 phenylpyridine
5 (1 adamantylthio) 3 picoline
Antibiotic agent
Pyridine derivative
Unclassified drug
Animal cell
Antibacterial activity
Article
Cell viability
Controlled study
Cytotoxicity
Dose response
Fibroblast
IC 50
Methicillin resistant Staphylococcus aureus
Minimum inhibitory concentration
Nonhuman
Priority journal
5 (1 adamantylthio) 3 picoline
Antibiotic agent
Pyridine derivative
Unclassified drug
Animal cell
Antibacterial activity
Article
Cell viability
Controlled study
Cytotoxicity
Dose response
Fibroblast
IC 50
Methicillin resistant Staphylococcus aureus
Minimum inhibitory concentration
Nonhuman
Priority journal