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Anti-Helicobacter pylori xanthones of Garcinia fusca

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dc.contributor.authorNontakham J.
dc.contributor.authorCharoenram N.
dc.contributor.authorUpamai W.
dc.contributor.authorTaweechotipatr M.
dc.contributor.authorSuksamrarn S.
dc.date.accessioned2021-04-05T03:32:26Z
dc.date.available2021-04-05T03:32:26Z
dc.date.issued2014
dc.date.issuedBE2557
dc.description.abstractA new geranylated xanthone derivative, fuscaxanthone I (1), along with nine xanthones (2-9 and 11), a biphenyl (10) and three biflavonoids (12-14) were isolated from the roots of Garcinia fusca Pierre. Compounds 8, 10 and 11-14 were reported from this plant species for the first time. Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR and MS. The isolated compounds were evaluated for antibacterial activity against Helicobacter pylori. Cowaxanthone (5) and fukugiside (14) exhibited stronger inhibitory activity against H. pylori DMST reference strain at MICs 4.6 and 10.8 μM, respectively, than that of the control metronidazole. Isojacareubin (8) displayed the most potent activity against H. pylori HP40 clinical isolate with MIC 23.9 μM, which was approximately two times greater than that of the standard drug amoxicillin. © 2013 The Pharmaceutical Society of Korea.
dc.format.mimetypeapplication/pdf
dc.identifier.citationArchives of Pharmacal Research. Vol 37, No.8 (2014), p.972-977
dc.identifier.doi10.1007/s12272-013-0266-4
dc.identifier.issn2536269
dc.identifier.other2-s2.0-84886913190
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6306
dc.rights.holderScopus
dc.subject.otherAntiinfective agent
dc.subject.otherXanthone derivative
dc.subject.otherChemistry
dc.subject.otherDrug effects
dc.subject.otherGarcinia
dc.subject.otherHelicobacter pylori
dc.subject.otherIsolation and purification
dc.subject.otherMass spectrometry
dc.subject.otherMicrobial sensitivity test
dc.subject.otherNuclear magnetic resonance spectroscopy
dc.subject.otherPlant root
dc.subject.otherAnti-Bacterial Agents
dc.subject.otherGarcinia
dc.subject.otherHelicobacter pylori
dc.subject.otherMagnetic Resonance Spectroscopy
dc.subject.otherMass Spectrometry
dc.subject.otherMicrobial Sensitivity Tests
dc.subject.otherPlant Roots
dc.subject.otherXanthones
dc.titleAnti-Helicobacter pylori xanthones of Garcinia fusca
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84886913190&doi=10.1007%2fs12272-013-0266-4&partnerID=40&md5=6680d89608ae6dcaf2bfa5fb4daf7ed2

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