Publication: Anti-Helicobacter pylori xanthones of Garcinia fusca
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Issued Date
2014
Resource Type
File Type
application/pdf
ISSN
2536269
Other identifier(s)
2-s2.0-84886913190
Rights Holder(s)
Scopus
Bibliographic Citation
Archives of Pharmacal Research. Vol 37, No.8 (2014), p.972-977
Suggested Citation
Nontakham J., Charoenram N., Upamai W., Taweechotipatr M., Suksamrarn S. Anti-Helicobacter pylori xanthones of Garcinia fusca. Archives of Pharmacal Research. Vol 37, No.8 (2014), p.972-977. doi:10.1007/s12272-013-0266-4 Retrieved from: https://hdl.handle.net/20.500.14740/6306
Abstract
A new geranylated xanthone derivative, fuscaxanthone I (1), along with nine xanthones (2-9 and 11), a biphenyl (10) and three biflavonoids (12-14) were isolated from the roots of Garcinia fusca Pierre. Compounds 8, 10 and 11-14 were reported from this plant species for the first time. Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR and MS. The isolated compounds were evaluated for antibacterial activity against Helicobacter pylori. Cowaxanthone (5) and fukugiside (14) exhibited stronger inhibitory activity against H. pylori DMST reference strain at MICs 4.6 and 10.8 μM, respectively, than that of the control metronidazole. Isojacareubin (8) displayed the most potent activity against H. pylori HP40 clinical isolate with MIC 23.9 μM, which was approximately two times greater than that of the standard drug amoxicillin. © 2013 The Pharmaceutical Society of Korea.
Subject(s)
Antiinfective agent
Xanthone derivative
Chemistry
Drug effects
Garcinia
Helicobacter pylori
Isolation and purification
Mass spectrometry
Microbial sensitivity test
Nuclear magnetic resonance spectroscopy
Plant root
Anti-Bacterial Agents
Garcinia
Helicobacter pylori
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Plant Roots
Xanthones
Xanthone derivative
Chemistry
Drug effects
Garcinia
Helicobacter pylori
Isolation and purification
Mass spectrometry
Microbial sensitivity test
Nuclear magnetic resonance spectroscopy
Plant root
Anti-Bacterial Agents
Garcinia
Helicobacter pylori
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Plant Roots
Xanthones