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Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana

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dc.contributor.authorSuksamrarn S.
dc.contributor.authorKomutiban O.
dc.contributor.authorRatananukul P.
dc.contributor.authorChimnoi N.
dc.contributor.authorLartpornmatulee N.
dc.contributor.authorSuksamrarn A.
dc.date.accessioned2021-04-05T04:32:23Z
dc.date.available2021-04-05T04:32:23Z
dc.date.issued2006
dc.date.issuedBE2549
dc.description.abstractThree new prenylated xanthones, mangostenones C (1), D (2), and E (3), together with 16 known xanthones 4-19, were isolated from the young fruit (7-week maturity stage) of Garcinia mangostana. The structural elucidation of the new compounds was mainly established on the basis of 1D and 2D NMR and HR-MS spectroscopic analysis. Compound 1 showed cytotoxic properties against three human cancer cell lines, epidermoid carcinoma of the mouth (KB), breast cancer (BC-1), and small cell lung cancer (NCI-H187), with IC50 values of 2.8, 3.53, and 3.72 μg/ml, respectively. Among the isolates, α-mangostin (12), the major metabolite, exhibited the most potent effects against the BC-1 cells with an IC50 value of 0.92 μg/ml, an activity greater than that of the standard drug ellipticine (IC 50=1.46 mg/ml). Compound 12 also showed the highest activity against KB cells, while gartanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC50 values of 2.08 μg/ml and 1.08 μg/ml. © 2006 Pharmaceutical Society of Japan.
dc.format.mimetypeapplication/pdf
dc.identifier.citationChemical and Pharmaceutical Bulletin. Vol 54, No.3 (2006), p.301-305
dc.identifier.doi10.1248/cpb.54.301
dc.identifier.issn92363
dc.identifier.other2-s2.0-33645225308
dc.identifier.urihttps://hdl.handle.net/20.500.14740/5893
dc.rights.holderScopus
dc.subject.other11 hydroxy 1 isomangostin
dc.subject.other8 desoxygartanin
dc.subject.otherAlpha mangostin
dc.subject.otherAntineoplastic agent
dc.subject.otherDemethylcalabaxanthone
dc.subject.otherGamma mangostin
dc.subject.otherGarcinone b
dc.subject.otherGarcinone c
dc.subject.otherGarcinone d
dc.subject.otherGarcinone e
dc.subject.otherGartanin
dc.subject.otherMangostanin
dc.subject.otherMangostanol
dc.subject.otherMangostenones c
dc.subject.otherMangostenones d
dc.subject.otherMangostenones e
dc.subject.otherMangostin
dc.subject.otherMangostinone
dc.subject.otherThwaitesixanthone
dc.subject.otherUnclassified drug
dc.subject.otherXanthone derivative
dc.subject.otherArticle
dc.subject.otherBreast cancer
dc.subject.otherCancer cell culture
dc.subject.otherControlled study
dc.subject.otherCytotoxicity
dc.subject.otherDrug effect
dc.subject.otherDrug isolation
dc.subject.otherDrug structure
dc.subject.otherFruit
dc.subject.otherGarcinia mangostana
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherIC 50
dc.subject.otherLung small cell cancer
dc.subject.otherMass spectrometry
dc.subject.otherNonhuman
dc.subject.otherNuclear magnetic resonance
dc.subject.otherSquamous cell carcinoma
dc.subject.otherAntineoplastic Agents, Phytogenic
dc.subject.otherCarbohydrate Conformation
dc.subject.otherCell Line, Tumor
dc.subject.otherDrug Screening Assays, Antitumor
dc.subject.otherFruit
dc.subject.otherGarcinia
dc.subject.otherHumans
dc.subject.otherMagnetic Resonance Spectroscopy
dc.subject.otherSpectrometry, Mass, Fast Atom Bombardment
dc.subject.otherSpectrophotometry, Infrared
dc.subject.otherSpectrophotometry, Ultraviolet
dc.subject.otherXanthines
dc.titleCytotoxic prenylated xanthones from the young fruit of Garcinia mangostana
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33645225308&doi=10.1248%2fcpb.54.301&partnerID=40&md5=1b715d7fd1657772b8ec277a8814a08d

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