Publication: Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana
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Issued Date
2006
Resource Type
File Type
application/pdf
ISSN
92363
Other identifier(s)
2-s2.0-33645225308
Rights Holder(s)
Scopus
Bibliographic Citation
Chemical and Pharmaceutical Bulletin. Vol 54, No.3 (2006), p.301-305
Suggested Citation
Suksamrarn S., Komutiban O., Ratananukul P., Chimnoi N., Lartpornmatulee N., Suksamrarn A. Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana. Chemical and Pharmaceutical Bulletin. Vol 54, No.3 (2006), p.301-305. doi:10.1248/cpb.54.301 Retrieved from: https://hdl.handle.net/20.500.14740/5893
Abstract
Three new prenylated xanthones, mangostenones C (1), D (2), and E (3), together with 16 known xanthones 4-19, were isolated from the young fruit (7-week maturity stage) of Garcinia mangostana. The structural elucidation of the new compounds was mainly established on the basis of 1D and 2D NMR and HR-MS spectroscopic analysis. Compound 1 showed cytotoxic properties against three human cancer cell lines, epidermoid carcinoma of the mouth (KB), breast cancer (BC-1), and small cell lung cancer (NCI-H187), with IC50 values of 2.8, 3.53, and 3.72 μg/ml, respectively. Among the isolates, α-mangostin (12), the major metabolite, exhibited the most potent effects against the BC-1 cells with an IC50 value of 0.92 μg/ml, an activity greater than that of the standard drug ellipticine (IC 50=1.46 mg/ml). Compound 12 also showed the highest activity against KB cells, while gartanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC50 values of 2.08 μg/ml and 1.08 μg/ml. © 2006 Pharmaceutical Society of Japan.
Subject(s)
11 hydroxy 1 isomangostin
8 desoxygartanin
Alpha mangostin
Antineoplastic agent
Demethylcalabaxanthone
Gamma mangostin
Garcinone b
Garcinone c
Garcinone d
Garcinone e
Gartanin
Mangostanin
Mangostanol
Mangostenones c
Mangostenones d
Mangostenones e
Mangostin
Mangostinone
Thwaitesixanthone
Unclassified drug
Xanthone derivative
Article
Breast cancer
Cancer cell culture
Controlled study
Cytotoxicity
Drug effect
Drug isolation
Drug structure
Fruit
Garcinia mangostana
Human
Human cell
IC 50
Lung small cell cancer
Mass spectrometry
Nonhuman
Nuclear magnetic resonance
Squamous cell carcinoma
Antineoplastic Agents, Phytogenic
Carbohydrate Conformation
Cell Line, Tumor
Drug Screening Assays, Antitumor
Fruit
Garcinia
Humans
Magnetic Resonance Spectroscopy
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Xanthines
8 desoxygartanin
Alpha mangostin
Antineoplastic agent
Demethylcalabaxanthone
Gamma mangostin
Garcinone b
Garcinone c
Garcinone d
Garcinone e
Gartanin
Mangostanin
Mangostanol
Mangostenones c
Mangostenones d
Mangostenones e
Mangostin
Mangostinone
Thwaitesixanthone
Unclassified drug
Xanthone derivative
Article
Breast cancer
Cancer cell culture
Controlled study
Cytotoxicity
Drug effect
Drug isolation
Drug structure
Fruit
Garcinia mangostana
Human
Human cell
IC 50
Lung small cell cancer
Mass spectrometry
Nonhuman
Nuclear magnetic resonance
Squamous cell carcinoma
Antineoplastic Agents, Phytogenic
Carbohydrate Conformation
Cell Line, Tumor
Drug Screening Assays, Antitumor
Fruit
Garcinia
Humans
Magnetic Resonance Spectroscopy
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Xanthines