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Effect of serotonin depletion on nitric oxide induced cerebrovascular nociceptive response

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dc.contributor.authorSrikiatkhachorn A.
dc.contributor.authorAnuntasethakul T.
dc.contributor.authorPhansuwan-Pujito P.
dc.contributor.authorPatumraj S.
dc.contributor.authorKasantikul V.
dc.date.accessioned2021-04-05T04:33:14Z
dc.date.available2021-04-05T04:33:14Z
dc.date.issued2001
dc.date.issuedBE2544
dc.description.abstractThe study was conducted to investigate the effect of serotonin depletion on nitric oxide-induced meningeal vascular response and cerebrovascular nociception. Nitroglycerin was infused i.v. to control and serotonin-depleted rats. Pial circulation was monitored by intravital fluorescent videomicroscopy and Fos immunoreactivity trigeminal nucleus caudalis neurons was used as an indicator for the cerebrovascular nociception. The results showed that the degree of nitric oxide-induced pial microvascular dilatation was significantly greater in the seroton-indepleted group than the control. The number of nitric oxide-evoked Fos-immunoreactive cells between the two groups remained comparable. The results suggest that though depletion of serotonin can facilitate the vascular response to nitric oxide it does not alter the nitric oxide-induced craniovascular nociceptive response. © 2001 Lippincott Williams & Wilkins.
dc.format.mimetypeapplication/pdf
dc.identifier.citationNeuroReport. Vol 12, No.5 (2001), p.967-971
dc.identifier.doi10.1097/00001756-200104170-00021
dc.identifier.issn9594965
dc.identifier.other2-s2.0-0035901742
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6907
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherGlyceryl trinitrate
dc.subject.otherNitric oxide
dc.subject.otherProtein fos
dc.subject.otherSerotonin
dc.subject.otherAnimal experiment
dc.subject.otherAnimal model
dc.subject.otherAnimal tissue
dc.subject.otherArticle
dc.subject.otherBlood vessel reactivity
dc.subject.otherBrain circulation
dc.subject.otherControlled study
dc.subject.otherHeadache
dc.subject.otherImmunoreactivity
dc.subject.otherMale
dc.subject.otherMigraine
dc.subject.otherNociceptive stimulation
dc.subject.otherNonhuman
dc.subject.otherOxidative stress
dc.subject.otherPathogenesis
dc.subject.otherPia mater
dc.subject.otherPriority journal
dc.subject.otherRat
dc.subject.otherSerotonin release
dc.subject.otherTrigeminal nucleus
dc.subject.otherVasodilatation
dc.titleEffect of serotonin depletion on nitric oxide induced cerebrovascular nociceptive response
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0035901742&doi=10.1097%2f00001756-200104170-00021&partnerID=40&md5=15e39d31a96be9e2dbaf0098c1c504f1

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