Publication: Effect of serotonin depletion on nitric oxide induced cerebrovascular nociceptive response
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0
Issued Date
2001
Resource Type
File Type
application/pdf
ISSN
9594965
Other identifier(s)
2-s2.0-0035901742
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
NeuroReport. Vol 12, No.5 (2001), p.967-971
Suggested Citation
Srikiatkhachorn A., Anuntasethakul T., Phansuwan-Pujito P., Patumraj S., Kasantikul V. Effect of serotonin depletion on nitric oxide induced cerebrovascular nociceptive response. NeuroReport. Vol 12, No.5 (2001), p.967-971. doi:10.1097/00001756-200104170-00021 Retrieved from: https://hdl.handle.net/20.500.14740/6907
Abstract
The study was conducted to investigate the effect of serotonin depletion on nitric oxide-induced meningeal vascular response and cerebrovascular nociception. Nitroglycerin was infused i.v. to control and serotonin-depleted rats. Pial circulation was monitored by intravital fluorescent videomicroscopy and Fos immunoreactivity trigeminal nucleus caudalis neurons was used as an indicator for the cerebrovascular nociception. The results showed that the degree of nitric oxide-induced pial microvascular dilatation was significantly greater in the seroton-indepleted group than the control. The number of nitric oxide-evoked Fos-immunoreactive cells between the two groups remained comparable. The results suggest that though depletion of serotonin can facilitate the vascular response to nitric oxide it does not alter the nitric oxide-induced craniovascular nociceptive response. © 2001 Lippincott Williams & Wilkins.
Subject(s)
Glyceryl trinitrate
Nitric oxide
Protein fos
Serotonin
Animal experiment
Animal model
Animal tissue
Article
Blood vessel reactivity
Brain circulation
Controlled study
Headache
Immunoreactivity
Male
Migraine
Nociceptive stimulation
Nonhuman
Oxidative stress
Pathogenesis
Pia mater
Priority journal
Rat
Serotonin release
Trigeminal nucleus
Vasodilatation
Nitric oxide
Protein fos
Serotonin
Animal experiment
Animal model
Animal tissue
Article
Blood vessel reactivity
Brain circulation
Controlled study
Headache
Immunoreactivity
Male
Migraine
Nociceptive stimulation
Nonhuman
Oxidative stress
Pathogenesis
Pia mater
Priority journal
Rat
Serotonin release
Trigeminal nucleus
Vasodilatation