Publication:
Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia

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dc.contributor.authorPaiboonvong T.
dc.contributor.authorNosoongnoen W.
dc.contributor.authorSathirakul K.
dc.contributor.authorTangsujaritvijit V.
dc.contributor.authorKaemapairoj J.
dc.contributor.authorTragulpiankit P.
dc.contributor.authorMontakantikul P.
dc.date.accessioned2021-04-05T03:04:26Z
dc.date.available2021-04-05T03:04:26Z
dc.date.issued2019
dc.date.issuedBE2562
dc.description.abstractSitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC0 – 8) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.) Copyright © 2019 American Society for Microbiology. All Rights Reserved.
dc.format.mimetypeapplication/pdf
dc.identifier.citationAntimicrobial Agents and Chemotherapy. Vol 63, No.10 (2019)
dc.identifier.doi10.1128/AAC.00800-19
dc.identifier.issn664804
dc.identifier.other2-s2.0-85072588748
dc.identifier.urihttps://hdl.handle.net/20.500.14740/5640
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherSitafloxacin
dc.subject.otherAntiinfective agent
dc.subject.otherQuinolone derivative
dc.subject.otherSitafloxacin
dc.subject.otherAdult
dc.subject.otherAged
dc.subject.otherArea under the curve
dc.subject.otherArticle
dc.subject.otherBlood sampling
dc.subject.otherClinical article
dc.subject.otherCritically ill patient
dc.subject.otherDrug blood level
dc.subject.otherDrug penetration
dc.subject.otherElimination half-life
dc.subject.otherElimination rate constant
dc.subject.otherEpithelial lining fluid
dc.subject.otherFemale
dc.subject.otherHuman
dc.subject.otherLiquid
dc.subject.otherLung lavage fluid
dc.subject.otherMale
dc.subject.otherOral clearance
dc.subject.otherPharmacokinetic parameters
dc.subject.otherPneumonia
dc.subject.otherPriority journal
dc.subject.otherSingle drug dose
dc.subject.otherThai (citizen)
dc.subject.otherTime to maximum plasma concentration
dc.subject.otherVolume of distribution
dc.subject.otherBronchoalveolar lavage fluid
dc.subject.otherCritical illness
dc.subject.otherDrug effect
dc.subject.otherLung
dc.subject.otherLung alveolus macrophage
dc.subject.otherLung lavage
dc.subject.otherMetabolism
dc.subject.otherMicrobiology
dc.subject.otherMiddle aged
dc.subject.otherPneumonia
dc.subject.otherProcedures
dc.subject.otherRespiratory mucosa
dc.subject.otherThailand
dc.subject.otherAdult
dc.subject.otherAged
dc.subject.otherAnti-Bacterial Agents
dc.subject.otherBronchoalveolar Lavage
dc.subject.otherBronchoalveolar Lavage Fluid
dc.subject.otherCritical Illness
dc.subject.otherFemale
dc.subject.otherFluoroquinolones
dc.subject.otherHumans
dc.subject.otherLung
dc.subject.otherMacrophages, Alveolar
dc.subject.otherMale
dc.subject.otherMiddle Aged
dc.subject.otherPneumonia
dc.subject.otherRespiratory Mucosa
dc.subject.otherThailand
dc.titlePharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
dc.typeArticle
dspace.entity.typePublication
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