Publication:
Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

664804

DOI

10.1128/AAC.00800-19

Other identifier(s)

2-s2.0-85072588748

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Antimicrobial Agents and Chemotherapy. Vol 63, No.10 (2019)

Suggested Citation

Paiboonvong T., Nosoongnoen W., Sathirakul K., Tangsujaritvijit V., Kaemapairoj J., Tragulpiankit P., Montakantikul P. Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia. Antimicrobial Agents and Chemotherapy. Vol 63, No.10 (2019). doi:10.1128/AAC.00800-19 Retrieved from: https://hdl.handle.net/20.500.14740/5640

Title

Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia

Author(s)

Paiboonvong T.
 Nosoongnoen W.
 Sathirakul K.
 Tangsujaritvijit V.
 Kaemapairoj J.
 Tragulpiankit P.
 Montakantikul P.

Abstract

Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC0 – 8) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.) Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Subject(s)

Sitafloxacin
 Antiinfective agent
 Quinolone derivative
 Sitafloxacin
 Adult
 Aged
 Area under the curve
 Article
 Blood sampling
 Clinical article
 Critically ill patient
 Drug blood level
 Drug penetration
 Elimination half-life
 Elimination rate constant
 Epithelial lining fluid
 Female
 Human
 Liquid
 Lung lavage fluid
 Male
 Oral clearance
 Pharmacokinetic parameters
 Pneumonia
 Priority journal
 Single drug dose
 Thai (citizen)
 Time to maximum plasma concentration
 Volume of distribution
 Bronchoalveolar lavage fluid
 Critical illness
 Drug effect
 Lung
 Lung alveolus macrophage
 Lung lavage
 Metabolism
 Microbiology
 Middle aged
 Pneumonia
 Procedures
 Respiratory mucosa
 Thailand
 Adult
 Aged
 Anti-Bacterial Agents
 Bronchoalveolar Lavage
 Bronchoalveolar Lavage Fluid
 Critical Illness
 Female
 Fluoroquinolones
 Humans
 Lung
 Macrophages, Alveolar
 Male
 Middle Aged
 Pneumonia
 Respiratory Mucosa
 Thailand

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URI

https://hdl.handle.net/20.500.14740/5640

Collections

Scopus: Year 1983-2021

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