Association between serum uric acid level and microalbuminuria to chronic vascular complications in Thai patients with type 2 diabetes

Abstract

Aims To investigate an association between serum uric acid/microalbuminuria and chronic micro/macro-vascular complications in type 2 diabetic patients. Methods This cross-sectional study enrolled 608 patients with type 2 diabetes. All subjects were examined and basic information on health of the subjects was recorded for inclusion criteria. Several chemical parameters (fasting plasma glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, uric acid, and microalbuminuria), and related chronic vascular complications were measured and recorded in data forms. Results Logistic regressions were used to analyse odds ratios between uric acid/microalbuminuria levels and several chronic vascular complications. Prevalence of chronic vascular complications in T2DM patients, namely coronary arterial disease, cerebrovascular disease, diabetic nephropathy, diabetic retinopathy, and diabetic peripheral neuropathy was significantly correlated with increase of uric acid level [2.29 (1.01-5.2), 16.01 (4.74-54.09), 9.99 (4.4-22.8), 4.43 (1.3-15.1), 4.37 (1.5-12.9)], and of microalbuminuria level [7.0 (3.6-13.8), 3.2 (1.2-8.7), NA, 14.7 (5.1-42.7), 7.2 (2.9-17.7)]. Conclusion Both elevated uric acid and microalbuminuria levels were significantly associated with diabetic chronic micro/macro-vascular complications. Monitoring of uric acid and microalbuminuria levels provides a predictive value for a presence of chronic micro/macro-vascular complications in patients with type 2 diabetes. © 2014 Elsevier Inc. All rights reserved.