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Intestinal perforation in the premature infant

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dc.contributor.authorVongbhavit K.
dc.contributor.authorUnderwood M.A.
dc.date.accessioned2021-04-05T03:23:11Z
dc.date.available2021-04-05T03:23:11Z
dc.date.issued2017
dc.date.issuedBE2560
dc.description.abstractOBJECTIVE: To compare demographic data, prenatal and postnatal characteristics, laboratory data, and outcomes in a cohort of premature infants with spontaneous ileal perforation (SIP), surgical necrotizing enterocolitis (sNEC) and matched controls. METHODS: A retrospective case-control study of infants with intestinal perforation with a birth weight (BW) less than 2,000 grams and gestational age (GA) less than 34 weeks and infants without perforation matched for BW (±150 grams) and GA (±1week). RESULTS: 130 premature infants were included, 30 infants with SIP, 35 infants with sNEC and 65 control infants. The median age of onset was 5 days postnatal age in SIP versus 25 days in sNEC (p < 0.001) and the peak onset was at 26 weeks correctedGAfor SIP and 30 weeks correctedGAfor sNEC. Infants with perforation had significantly higher rates of mortality (p < 0.001) and common morbidities associated with prematurity. Administration of corticosteroids and indomethacin did not differ among groups. SIP was more common among infants born to young mothers (p = 0.04) and less common in infants receiving caffeine (p = 0.02). sNECwas less common among infants receiving early red cell transfusion (p = 0.01). Perforation and sNEC trended towards less common in infants receiving inhaled nitric oxide. CONCLUSION: SIP and sNEC are distinct clinical entities. Potential protective effects of caffeine, inhaled nitric oxide, and early transfusion should be further studied. © 2017 IOS Press and the authors. All rights reserved.
dc.format.mimetypeapplication/pdf
dc.identifier.citationJournal of Neonatal-Perinatal Medicine. Vol 10, No.3 (2017), p.281-289
dc.identifier.doi10.3233/NPM-16148
dc.identifier.issn19345798
dc.identifier.other2-s2.0-85031823237
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4833
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherAntifungal agent
dc.subject.otherC reactive protein
dc.subject.otherCaffeine
dc.subject.otherCorticosteroid
dc.subject.otherGlycerol
dc.subject.otherIndometacin
dc.subject.otherNitric oxide
dc.subject.otherEndothelium derived relaxing factor
dc.subject.otherNitric oxide
dc.subject.otherApgar score
dc.subject.otherArticle
dc.subject.otherBirth weight
dc.subject.otherBody weight
dc.subject.otherCase control study
dc.subject.otherControlled study
dc.subject.otherErythrocyte transfusion
dc.subject.otherGestational age
dc.subject.otherHead circumference
dc.subject.otherHospitalization
dc.subject.otherHuman
dc.subject.otherHypertension
dc.subject.otherIncidence
dc.subject.otherInfant
dc.subject.otherLength of stay
dc.subject.otherMajor clinical study
dc.subject.otherMorbidity
dc.subject.otherMortality
dc.subject.otherNecrotizing enterocolitis
dc.subject.otherOnset age
dc.subject.otherPrematurity
dc.subject.otherPriority journal
dc.subject.otherRetrospective study
dc.subject.otherSmall intestine perforation
dc.subject.otherSpontaneous ileal perforation
dc.subject.otherSpontaneous ileal perforation
dc.subject.otherSpontaneous perforation
dc.subject.otherSurgical necrotizing enterocolitis
dc.subject.otherSurgical necrotizing enterocolitis
dc.subject.otherAdult
dc.subject.otherCohort analysis
dc.subject.otherEnterostomy
dc.subject.otherFemale
dc.subject.otherHypertension
dc.subject.otherIleum disease
dc.subject.otherInhalational drug administration
dc.subject.otherIntestine perforation
dc.subject.otherLow birth weight
dc.subject.otherMale
dc.subject.otherMaternal age
dc.subject.otherNecrotizing enterocolitis
dc.subject.otherNewborn
dc.subject.otherPregnancy
dc.subject.otherPregnancy complication
dc.subject.otherPrematurity
dc.subject.otherRisk factor
dc.subject.otherRupture
dc.subject.otherYoung adult
dc.subject.otherAdministration, Inhalation
dc.subject.otherAdult
dc.subject.otherAge of Onset
dc.subject.otherCase-Control Studies
dc.subject.otherCohort Studies
dc.subject.otherEndothelium-Dependent Relaxing Factors
dc.subject.otherEnterocolitis, Necrotizing
dc.subject.otherEnterostomy
dc.subject.otherFemale
dc.subject.otherHumans
dc.subject.otherHypertension
dc.subject.otherIleal Diseases
dc.subject.otherInfant, Extremely Premature
dc.subject.otherInfant, Low Birth Weight
dc.subject.otherInfant, Newborn
dc.subject.otherInfant, Premature
dc.subject.otherIntestinal Perforation
dc.subject.otherMale
dc.subject.otherMaternal Age
dc.subject.otherNitric Oxide
dc.subject.otherPregnancy
dc.subject.otherPregnancy Complications
dc.subject.otherRetrospective Studies
dc.subject.otherRisk Factors
dc.subject.otherRupture, Spontaneous
dc.subject.otherYoung Adult
dc.titleIntestinal perforation in the premature infant
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85031823237&doi=10.3233%2fNPM-16148&partnerID=40&md5=e4551ea4c3aae244947c9dcc47cea793

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