Publication:
Intestinal perforation in the premature infant

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

19345798

DOI

10.3233/NPM-16148

Other identifier(s)

2-s2.0-85031823237

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of Neonatal-Perinatal Medicine. Vol 10, No.3 (2017), p.281-289

Suggested Citation

Vongbhavit K., Underwood M.A. Intestinal perforation in the premature infant. Journal of Neonatal-Perinatal Medicine. Vol 10, No.3 (2017), p.281-289. doi:10.3233/NPM-16148 Retrieved from: https://hdl.handle.net/20.500.14740/4833

Title

Intestinal perforation in the premature infant

Author(s)

Vongbhavit K.
 Underwood M.A.

Abstract

OBJECTIVE: To compare demographic data, prenatal and postnatal characteristics, laboratory data, and outcomes in a cohort of premature infants with spontaneous ileal perforation (SIP), surgical necrotizing enterocolitis (sNEC) and matched controls. METHODS: A retrospective case-control study of infants with intestinal perforation with a birth weight (BW) less than 2,000 grams and gestational age (GA) less than 34 weeks and infants without perforation matched for BW (±150 grams) and GA (±1week). RESULTS: 130 premature infants were included, 30 infants with SIP, 35 infants with sNEC and 65 control infants. The median age of onset was 5 days postnatal age in SIP versus 25 days in sNEC (p < 0.001) and the peak onset was at 26 weeks correctedGAfor SIP and 30 weeks correctedGAfor sNEC. Infants with perforation had significantly higher rates of mortality (p < 0.001) and common morbidities associated with prematurity. Administration of corticosteroids and indomethacin did not differ among groups. SIP was more common among infants born to young mothers (p = 0.04) and less common in infants receiving caffeine (p = 0.02). sNECwas less common among infants receiving early red cell transfusion (p = 0.01). Perforation and sNEC trended towards less common in infants receiving inhaled nitric oxide. CONCLUSION: SIP and sNEC are distinct clinical entities. Potential protective effects of caffeine, inhaled nitric oxide, and early transfusion should be further studied. © 2017 IOS Press and the authors. All rights reserved.

Subject(s)

Antifungal agent
 C reactive protein
 Caffeine
 Corticosteroid
 Glycerol
 Indometacin
 Nitric oxide
 Endothelium derived relaxing factor
 Nitric oxide
 Apgar score
 Article
 Birth weight
 Body weight
 Case control study
 Controlled study
 Erythrocyte transfusion
 Gestational age
 Head circumference
 Hospitalization
 Human
 Hypertension
 Incidence
 Infant
 Length of stay
 Major clinical study
 Morbidity
 Mortality
 Necrotizing enterocolitis
 Onset age
 Prematurity
 Priority journal
 Retrospective study
 Small intestine perforation
 Spontaneous ileal perforation
 Spontaneous ileal perforation
 Spontaneous perforation
 Surgical necrotizing enterocolitis
 Surgical necrotizing enterocolitis
 Adult
 Cohort analysis
 Enterostomy
 Female
 Hypertension
 Ileum disease
 Inhalational drug administration
 Intestine perforation
 Low birth weight
 Male
 Maternal age
 Necrotizing enterocolitis
 Newborn
 Pregnancy
 Pregnancy complication
 Prematurity
 Risk factor
 Rupture
 Young adult
 Administration, Inhalation
 Adult
 Age of Onset
 Case-Control Studies
 Cohort Studies
 Endothelium-Dependent Relaxing Factors
 Enterocolitis, Necrotizing
 Enterostomy
 Female
 Humans
 Hypertension
 Ileal Diseases
 Infant, Extremely Premature
 Infant, Low Birth Weight
 Infant, Newborn
 Infant, Premature
 Intestinal Perforation
 Male
 Maternal Age
 Nitric Oxide
 Pregnancy
 Pregnancy Complications
 Retrospective Studies
 Risk Factors
 Rupture, Spontaneous
 Young Adult

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URI

https://hdl.handle.net/20.500.14740/4833

Collections

Scopus: Year 1983-2021

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