Publication: New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of: Ziziphus cambodiana
| dc.contributor.author | Lomchoey N. | |
| dc.contributor.author | Panseeta P. | |
| dc.contributor.author | Boonsri P. | |
| dc.contributor.author | Apiratikul N. | |
| dc.contributor.author | Prabpai S. | |
| dc.contributor.author | Kongsaeree P. | |
| dc.contributor.author | Suksamrarn S. | |
| dc.date.accessioned | 2021-04-05T03:21:49Z | |
| dc.date.available | 2021-04-05T03:21:49Z | |
| dc.date.issued | 2018 | |
| dc.date.issuedBE | 2561 | |
| dc.description.abstract | Six new 14-membered ring cyclopeptide alkaloids, cambodines A-F (1-6), and two known compounds, frangufoline (7) and lotusanine B (8), were isolated from the root bark extract of Ziziphus cambodiana Pierre. Their structures and configurations were established based on 1D and 2D NMR, HRMS, ECD, and X-ray crystallographic data. Compounds 1 and 3 are rare 5(14)-type cyclopeptide alkaloids that possess an imidazolidin-4-one ring in the terminal unit. The cyclopeptides were tested for their in vitro antiplasmodial, antitubercular, and cytotoxic effects against three cancer cell lines. Compound 3 showed significant antiplasmodial activity against the malarial parasite Plasmodium falciparum, with an IC50 value of 6.09 μM. © The Royal Society of Chemistry 2018. | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.citation | RSC Advances. Vol 8, No.33 (2018), p.18204-18215 | |
| dc.identifier.doi | 10.1039/c7ra13050c | |
| dc.identifier.issn | 20462069 | |
| dc.identifier.other | 2-s2.0-85047479838 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14740/3906 | |
| dc.rights.holder | มหาวิทยาลัยศรีนครินทรวิโรฒ | |
| dc.subject.other | Alkaloids | |
| dc.subject.other | Cell culture | |
| dc.subject.other | Cytotoxicity | |
| dc.subject.other | Nuclear magnetic resonance spectroscopy | |
| dc.subject.other | X ray crystallography | |
| dc.subject.other | Anti tuberculars | |
| dc.subject.other | Antiplasmodial activity | |
| dc.subject.other | Cancer cell lines | |
| dc.subject.other | Crystallographic data | |
| dc.subject.other | Cytotoxic effects | |
| dc.subject.other | Malarial parasites | |
| dc.subject.other | Plasmodium falciparum | |
| dc.subject.other | Terminal units | |
| dc.subject.other | Metabolites | |
| dc.title | New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of: Ziziphus cambodiana | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| swu.datasource.scopus | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047479838&doi=10.1039%2fc7ra13050c&partnerID=40&md5=1c4fe74c435bfbc7cbf3abac078a7e7f |