Publication: New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of: Ziziphus cambodiana
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Issued Date
2018
Resource Type
File Type
application/pdf
ISSN
20462069
Other identifier(s)
2-s2.0-85047479838
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
RSC Advances. Vol 8, No.33 (2018), p.18204-18215
Suggested Citation
Lomchoey N., Panseeta P., Boonsri P., Apiratikul N., Prabpai S., Kongsaeree P., Suksamrarn S. New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of: Ziziphus cambodiana. RSC Advances. Vol 8, No.33 (2018), p.18204-18215. doi:10.1039/c7ra13050c Retrieved from: https://hdl.handle.net/20.500.14740/3906
Abstract
Six new 14-membered ring cyclopeptide alkaloids, cambodines A-F (1-6), and two known compounds, frangufoline (7) and lotusanine B (8), were isolated from the root bark extract of Ziziphus cambodiana Pierre. Their structures and configurations were established based on 1D and 2D NMR, HRMS, ECD, and X-ray crystallographic data. Compounds 1 and 3 are rare 5(14)-type cyclopeptide alkaloids that possess an imidazolidin-4-one ring in the terminal unit. The cyclopeptides were tested for their in vitro antiplasmodial, antitubercular, and cytotoxic effects against three cancer cell lines. Compound 3 showed significant antiplasmodial activity against the malarial parasite Plasmodium falciparum, with an IC50 value of 6.09 μM. © The Royal Society of Chemistry 2018.