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Combating Helicobacter pylori infections with mucoadhesive nanoparticles loaded with Garcinia mangostana extract

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dc.contributor.authorPan-In P.
dc.contributor.authorTachapruetinun A.
dc.contributor.authorChaichanawongsaroj N.
dc.contributor.authorBanlunara W.
dc.contributor.authorSuksamrarn S.
dc.contributor.authorWanichwecharungruang S.
dc.date.accessioned2021-04-05T03:32:39Z
dc.date.available2021-04-05T03:32:39Z
dc.date.issued2014
dc.date.issuedBE2557
dc.description.abstractAim: To combat the resistance of Helicobacter pylori to antibiotics through the use of Garcinia mangostana extract (GME) in the form that can be localized at stomach mucosa. Materials & methods: GME and its major active component, α-mangostin, are encapsulated into the moderately acid stable mucoadhesive nanocarriers, and tested for anti-H. pylori and antiadhesion activities in vitro and their ability to eradicate H. pylori in infected mice. Results: The two in vitro activities are observed and are enhanced when the materials are encapsulated into nanocarriers. Preliminary in vivo tests revealed the ability to combat H. pylori in mice following oral administration of the encapsulated GME, but not the unencapsulated GME. Conclusion: Nanoencapsulated GME is a potential anti-H. pylori agent. Original submitted 10 August 2012; Revised submitted 9 December 2012; Published online 3 June 201. © 2014 Future Medicine Ltd.
dc.format.mimetypeapplication/pdf
dc.identifier.citationNanomedicine. Vol 9, No.3 (2014), p.457-468
dc.identifier.doi10.2217/nnm.13.30
dc.identifier.issn17435889
dc.identifier.other2-s2.0-84898936119
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6285
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherAlpha mangostin
dc.subject.otherAmoxicillin
dc.subject.otherAntiinfective agent
dc.subject.otherClarithromycin
dc.subject.otherGarcinia mangostana extract
dc.subject.otherMetronidazole
dc.subject.otherNanocarrier
dc.subject.otherPlant extract
dc.subject.otherUnclassified drug
dc.subject.otherAdhesin
dc.subject.otherDrug carrier
dc.subject.otherMangostin
dc.subject.otherNanoparticle
dc.subject.otherPlant extract
dc.subject.otherXanthone derivative
dc.subject.otherAcidity
dc.subject.otherAnimal cell
dc.subject.otherAnimal experiment
dc.subject.otherAnimal model
dc.subject.otherAnimal tissue
dc.subject.otherAntiadhesion activity
dc.subject.otherAntibacterial activity
dc.subject.otherArticle
dc.subject.otherBacterial strain
dc.subject.otherBacterium detection
dc.subject.otherColumn chromatography
dc.subject.otherControlled study
dc.subject.otherDifferential scanning calorimetry
dc.subject.otherDrug activity
dc.subject.otherDrug delivery system
dc.subject.otherDrug isolation
dc.subject.otherDrug stability
dc.subject.otherGarcinia mangostana
dc.subject.otherHelicobacter infection
dc.subject.otherHelicobacter pylori
dc.subject.otherHigh performance liquid chromatography
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherIn vitro study
dc.subject.otherIn vivo study
dc.subject.otherMinimum inhibitory concentration
dc.subject.otherMouse
dc.subject.otherMucoadhesion
dc.subject.otherNanoencapsulation
dc.subject.otherNonhuman
dc.subject.otherPriority journal
dc.subject.otherScanning electron microscope
dc.subject.otherScanning electron microscopy
dc.subject.otherSpectrophotometer
dc.subject.otherStomach mucosa
dc.subject.otherSustained drug release
dc.subject.otherAnimal
dc.subject.otherC57BL mouse
dc.subject.otherCell line
dc.subject.otherChemistry
dc.subject.otherDrug effects
dc.subject.otherGarcinia mangostana
dc.subject.otherHelicobacter Infections
dc.subject.otherMicrobiology
dc.subject.otherPhysiology
dc.subject.otherStomach
dc.subject.otherAdhesins, Bacterial
dc.subject.otherAnimals
dc.subject.otherCell Line
dc.subject.otherDrug Carriers
dc.subject.otherGarcinia mangostana
dc.subject.otherHelicobacter Infections
dc.subject.otherHelicobacter pylori
dc.subject.otherHumans
dc.subject.otherMice
dc.subject.otherMice, Inbred C57BL
dc.subject.otherNanoparticles
dc.subject.otherPlant Extracts
dc.subject.otherStomach
dc.subject.otherXanthones
dc.titleCombating Helicobacter pylori infections with mucoadhesive nanoparticles loaded with Garcinia mangostana extract
dc.typeArticle
dspace.entity.typePublication
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