Publication:
Combating Helicobacter pylori infections with mucoadhesive nanoparticles loaded with Garcinia mangostana extract

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Issued Date

2014

Resource Type

Article

File Type

application/pdf

ISSN

17435889

DOI

10.2217/nnm.13.30

Other identifier(s)

2-s2.0-84898936119

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Nanomedicine. Vol 9, No.3 (2014), p.457-468

Suggested Citation

Pan-In P., Tachapruetinun A., Chaichanawongsaroj N., Banlunara W., Suksamrarn S., Wanichwecharungruang S. Combating Helicobacter pylori infections with mucoadhesive nanoparticles loaded with Garcinia mangostana extract. Nanomedicine. Vol 9, No.3 (2014), p.457-468. doi:10.2217/nnm.13.30 Retrieved from: https://hdl.handle.net/20.500.14740/6285

Title

Combating Helicobacter pylori infections with mucoadhesive nanoparticles loaded with Garcinia mangostana extract

Author(s)

Pan-In P.
 Tachapruetinun A.
 Chaichanawongsaroj N.
 Banlunara W.
 Suksamrarn S.
 Wanichwecharungruang S.

Abstract

Aim: To combat the resistance of Helicobacter pylori to antibiotics through the use of Garcinia mangostana extract (GME) in the form that can be localized at stomach mucosa. Materials & methods: GME and its major active component, α-mangostin, are encapsulated into the moderately acid stable mucoadhesive nanocarriers, and tested for anti-H. pylori and antiadhesion activities in vitro and their ability to eradicate H. pylori in infected mice. Results: The two in vitro activities are observed and are enhanced when the materials are encapsulated into nanocarriers. Preliminary in vivo tests revealed the ability to combat H. pylori in mice following oral administration of the encapsulated GME, but not the unencapsulated GME. Conclusion: Nanoencapsulated GME is a potential anti-H. pylori agent. Original submitted 10 August 2012; Revised submitted 9 December 2012; Published online 3 June 201. © 2014 Future Medicine Ltd.

Subject(s)

Alpha mangostin
 Amoxicillin
 Antiinfective agent
 Clarithromycin
 Garcinia mangostana extract
 Metronidazole
 Nanocarrier
 Plant extract
 Unclassified drug
 Adhesin
 Drug carrier
 Mangostin
 Nanoparticle
 Plant extract
 Xanthone derivative
 Acidity
 Animal cell
 Animal experiment
 Animal model
 Animal tissue
 Antiadhesion activity
 Antibacterial activity
 Article
 Bacterial strain
 Bacterium detection
 Column chromatography
 Controlled study
 Differential scanning calorimetry
 Drug activity
 Drug delivery system
 Drug isolation
 Drug stability
 Garcinia mangostana
 Helicobacter infection
 Helicobacter pylori
 High performance liquid chromatography
 Human
 Human cell
 In vitro study
 In vivo study
 Minimum inhibitory concentration
 Mouse
 Mucoadhesion
 Nanoencapsulation
 Nonhuman
 Priority journal
 Scanning electron microscope
 Scanning electron microscopy
 Spectrophotometer
 Stomach mucosa
 Sustained drug release
 Animal
 C57BL mouse
 Cell line
 Chemistry
 Drug effects
 Garcinia mangostana
 Helicobacter Infections
 Microbiology
 Physiology
 Stomach
 Adhesins, Bacterial
 Animals
 Cell Line
 Drug Carriers
 Garcinia mangostana
 Helicobacter Infections
 Helicobacter pylori
 Humans
 Mice
 Mice, Inbred C57BL
 Nanoparticles
 Plant Extracts
 Stomach
 Xanthones

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URI

https://hdl.handle.net/20.500.14740/6285

Collections

Scopus: Year 1983-2021

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