Publication:
Evaluation of dermal irritancy potential of Carboxymethyl-chitosan hydrogel and poly-(acrylic acid) chitin hydrogel.

0
0

Issued Date

2007

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-36049023191

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of the Medical Association of Thailand = Chotmaihet thangphaet. Vol 90, No.4 (2007), p.724-729

Suggested Citation

Rattanatayarom W., Wattanasirichaigoon S. Evaluation of dermal irritancy potential of Carboxymethyl-chitosan hydrogel and poly-(acrylic acid) chitin hydrogel.. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. Vol 90, No.4 (2007), p.724-729. Retrieved from: https://hdl.handle.net/20.500.14740/4919

Title

Evaluation of dermal irritancy potential of Carboxymethyl-chitosan hydrogel and poly-(acrylic acid) chitin hydrogel.

Author(s)

Rattanatayarom W.
 Wattanasirichaigoon S.

Abstract

OBJECTIVE: The wound dressing synthesized from carboxymethylchitosan hydrogel (CM) and chitin-(polyacrylic acid) hydrogel (PAA) were examined for their dermal irritation potential response using the Draize test. MATERIAL AND METHOD: Eighteen male Sprague-Dawley rats were divided into three groups (6 rats/each). Rats in group 1 were designed as control, group 2 were treated with CM, and group 3 were treated with PAA. The test materials diameter 1 x 1 cm were topically applied on the skin in group 2 and 3. Two skin sites (1 x 1 cm in size) were located at the back. One site was intact and the other was abraded in such a way the stratum corneum had no bleeding. RESULT: After 24 and 72 hours of wrappings, the materials were removed and the test sites were evaluated in terms of erythema and edema using adopted Draize scoring system. At the end of the experiment, all rats were anesthesized with intravenous thiopental sodium. Blood samples from descending aorta were collected for liver and kidney function test and all organs were weighed. The results of this experiment showed 1) no irritation of both materials in this animal model; 2) no material-related induced liver and kidney dysfunction and 3) organ weights had no significant difference between the groups. CONCLUSION: Both CM and PAA should be considered safe to use in the purpose of wound dressing in further clinical trials.

Subject(s)

Acrylic acid derivative
 Biomaterial
 Carboxymethyl chitosan
 Carboxymethyl-chitosan
 Chitin
 Chitosan
 Drug derivative
 Unclassified drug
 Animal
 Article
 Bandage
 Chemically induced disorder
 Edema
 Erythema
 Hydrogel
 Male
 Materials testing
 Physiology
 Rat
 Skin
 Sprague Dawley rat
 Wound healing
 Acrylates
 Animals
 Bandages
 Biocompatible Materials
 Chitin
 Chitosan
 Edema
 Erythema
 Hydrogel
 Male
 Materials Testing
 Rats
 Rats, Sprague-Dawley
 Skin
 Wound Healing

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/4919

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By