Publication:
Polymorphisms of serotonin 4 receptor gene associated with schizophrenia in Thai ethnic

Simple item page
dc.contributor.authorTurakitwanakan W.
dc.contributor.authorPanichareon B.
dc.contributor.authorSukhumsirichart W.
dc.date.accessioned2021-04-05T03:02:56Z
dc.date.available2021-04-05T03:02:56Z
dc.date.issued2019
dc.date.issuedBE2562
dc.description.abstractBackground: Serotonin 5-HT4 receptor (HTR4) is involved in learning and memory process. The location of this gene is in schizophrenia-susceptible loci. Objective: The present study aimed to investigate the variation in HTR4 gene in association with schizophrenia in Thai population. Materials and Methods: A total of 75 schizophrenia patients and 170 normal controls volunteered in this study. DNAs were extracted from whole blood. The purified DNAs were amplified and genotyped by PCR using 3’-locked nucleic acid (LNA) modified SNP primers and by high resolution melting (HRM) analysis. The differences in genotype distribution between patients and controls were assessed by Chi-square test of the SPSS software version 11.5. Results: All studied SNPs were in Hardy-Weinberg equilibrium. Two SNPs, rs2277051 and rs2277049, showed significant association with schizophrenia (p = 0.001, and p = 0.015, respectively). The genotype C of rs2277051 and G of rs2277049 existed in schizophrenia more than in control. Conclusion: The authors found two SNPs in intronic region of serotonin 5-HT4 receptor gene, rs2277051 and rs2277049, that related to the susceptibility for schizophrenia in Thai population. © JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND| 2019.
dc.format.mimetypeapplication/pdf
dc.identifier.citationJournal of the Medical Association of Thailand. Vol 102, No.7 (2019), p.29-34
dc.identifier.issn1252208
dc.identifier.other2-s2.0-85070331913
dc.identifier.urihttps://hdl.handle.net/20.500.14740/5247
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherGenomic DNA
dc.subject.otherLocked nucleic acid
dc.subject.otherSerotonin 4 receptor
dc.subject.otherAdult
dc.subject.otherAgar gel electrophoresis
dc.subject.otherArticle
dc.subject.otherControlled study
dc.subject.otherDNA fragmentation assay
dc.subject.otherDNA purification
dc.subject.otherDSM-5
dc.subject.otherFemale
dc.subject.otherGene
dc.subject.otherGene amplification
dc.subject.otherGene frequency
dc.subject.otherGenetic polymorphism
dc.subject.otherGenotype
dc.subject.otherHigh resolution melting analysis
dc.subject.otherHTR4 gene
dc.subject.otherHuman
dc.subject.otherMajor clinical study
dc.subject.otherMale
dc.subject.otherPolymerase chain reaction
dc.subject.otherProtein polymorphism
dc.subject.otherSchizophrenia
dc.subject.otherSequence analysis
dc.titlePolymorphisms of serotonin 4 receptor gene associated with schizophrenia in Thai ethnic
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85070331913&partnerID=40&md5=998614f9737c0d7cf8a379ab680eeee8

Files

Collections

Scopus: Year 1983-2021