Publication: Polymorphisms of serotonin 4 receptor gene associated with schizophrenia in Thai ethnic
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0
Issued Date
2019
Resource Type
File Type
application/pdf
ISSN
1252208
Other identifier(s)
2-s2.0-85070331913
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol 102, No.7 (2019), p.29-34
Suggested Citation
Turakitwanakan W., Panichareon B., Sukhumsirichart W. Polymorphisms of serotonin 4 receptor gene associated with schizophrenia in Thai ethnic. Journal of the Medical Association of Thailand. Vol 102, No.7 (2019), p.29-34. Retrieved from: https://hdl.handle.net/20.500.14740/5247
Abstract
Background: Serotonin 5-HT4 receptor (HTR4) is involved in learning and memory process. The location of this gene is in schizophrenia-susceptible loci. Objective: The present study aimed to investigate the variation in HTR4 gene in association with schizophrenia in Thai population. Materials and Methods: A total of 75 schizophrenia patients and 170 normal controls volunteered in this study. DNAs were extracted from whole blood. The purified DNAs were amplified and genotyped by PCR using 3’-locked nucleic acid (LNA) modified SNP primers and by high resolution melting (HRM) analysis. The differences in genotype distribution between patients and controls were assessed by Chi-square test of the SPSS software version 11.5. Results: All studied SNPs were in Hardy-Weinberg equilibrium. Two SNPs, rs2277051 and rs2277049, showed significant association with schizophrenia (p = 0.001, and p = 0.015, respectively). The genotype C of rs2277051 and G of rs2277049 existed in schizophrenia more than in control. Conclusion: The authors found two SNPs in intronic region of serotonin 5-HT4 receptor gene, rs2277051 and rs2277049, that related to the susceptibility for schizophrenia in Thai population. © JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND| 2019.
Subject(s)
Genomic DNA
Locked nucleic acid
Serotonin 4 receptor
Adult
Agar gel electrophoresis
Article
Controlled study
DNA fragmentation assay
DNA purification
DSM-5
Female
Gene
Gene amplification
Gene frequency
Genetic polymorphism
Genotype
High resolution melting analysis
HTR4 gene
Human
Major clinical study
Male
Polymerase chain reaction
Protein polymorphism
Schizophrenia
Sequence analysis
Locked nucleic acid
Serotonin 4 receptor
Adult
Agar gel electrophoresis
Article
Controlled study
DNA fragmentation assay
DNA purification
DSM-5
Female
Gene
Gene amplification
Gene frequency
Genetic polymorphism
Genotype
High resolution melting analysis
HTR4 gene
Human
Major clinical study
Male
Polymerase chain reaction
Protein polymorphism
Schizophrenia
Sequence analysis