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Ziziphine N, O, P and Q, new antiplasmodial cyclopeptide alkaloids from Ziziphus oenoplia var. brunoniana

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dc.contributor.authorSuksamrarn S.
dc.contributor.authorSuwannapoch N.
dc.contributor.authorAunchai N.
dc.contributor.authorKuno M.
dc.contributor.authorRatananukul P.
dc.contributor.authorHaritakun R.
dc.contributor.authorJansakul C.
dc.contributor.authorRuchirawat S.
dc.date.accessioned2021-04-05T04:32:38Z
dc.date.available2021-04-05T04:32:38Z
dc.date.issued2005
dc.date.issuedBE2548
dc.description.abstractBioassay-guided fractionation of the EtOAc extract of the roots of Thai Ziziphus oenoplia var. brunoniana resulted in the isolation of four new 13-membered cyclopeptide alkaloids of the 5(13) type, ziziphine N-Q. The structures of the new metabolites were elucidated on the basis of spectroscopic analyses and the stereochemical assignments were established by comparison with other related compounds of known stereochemistry. Ziziphine N and Q exhibited significant antiplasmodial activity against the parasite Plasmodium falciparum with the inhibitory concentration (IC50) values of 3.92 and 3.5 μg/mL, respectively. Ziziphine N and Q also demonstrated weak antimycobacterial activity against Mycobacterium tuberculosis with the same MIC value of 200 μg/mL. © 2004 Elsevier Ltd. All rights reserved.
dc.format.mimetypeapplication/pdf
dc.identifier.citationTetrahedron. Vol 61, No.5 (2005), p.1175-1180
dc.identifier.doi10.1016/j.tet.2004.11.053
dc.identifier.issn404020
dc.identifier.other2-s2.0-12344255909
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6174
dc.rights.holderScopus
dc.subject.otherAlkaloid
dc.subject.otherAntimalarial agent
dc.subject.otherAntimycobacterial agent
dc.subject.otherCyclopeptide
dc.subject.otherPlant extract
dc.subject.otherUnclassified drug
dc.subject.otherZiziphine n
dc.subject.otherZiziphine o
dc.subject.otherZiziphine p
dc.subject.otherZiziphine q
dc.subject.otherArticle
dc.subject.otherControlled study
dc.subject.otherDrug activity
dc.subject.otherDrug isolation
dc.subject.otherDrug structure
dc.subject.otherFractionation
dc.subject.otherIC 50
dc.subject.otherJujube
dc.subject.otherMinimum inhibitory concentration
dc.subject.otherMycobacterium tuberculosis
dc.subject.otherNonhuman
dc.subject.otherPlant root
dc.subject.otherPlasmodium falciparum
dc.subject.otherPriority journal
dc.subject.otherSpectroscopy
dc.subject.otherStereochemistry
dc.subject.otherMycobacterium
dc.subject.otherMycobacterium tuberculosis
dc.subject.otherPlasmodium falciparum
dc.subject.otherRhamnaceae
dc.subject.otherZiziphus
dc.titleZiziphine N, O, P and Q, new antiplasmodial cyclopeptide alkaloids from Ziziphus oenoplia var. brunoniana
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-12344255909&doi=10.1016%2fj.tet.2004.11.053&partnerID=40&md5=811e0f9e8f192f831888bf34dbc82721

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