Publication:
Ziziphine N, O, P and Q, new antiplasmodial cyclopeptide alkaloids from Ziziphus oenoplia var. brunoniana

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Issued Date

2005

Resource Type

Article

File Type

application/pdf

ISSN

404020

DOI

10.1016/j.tet.2004.11.053

Other identifier(s)

2-s2.0-12344255909

Rights Holder(s)

Scopus

Bibliographic Citation

Tetrahedron. Vol 61, No.5 (2005), p.1175-1180

Suggested Citation

Suksamrarn S., Suwannapoch N., Aunchai N., Kuno M., Ratananukul P., Haritakun R., Jansakul C., Ruchirawat S. Ziziphine N, O, P and Q, new antiplasmodial cyclopeptide alkaloids from Ziziphus oenoplia var. brunoniana. Tetrahedron. Vol 61, No.5 (2005), p.1175-1180. doi:10.1016/j.tet.2004.11.053 Retrieved from: https://hdl.handle.net/20.500.14740/6174

Title

Ziziphine N, O, P and Q, new antiplasmodial cyclopeptide alkaloids from Ziziphus oenoplia var. brunoniana

Author(s)

Suksamrarn S.
 Suwannapoch N.
 Aunchai N.
 Kuno M.
 Ratananukul P.
 Haritakun R.
 Jansakul C.
 Ruchirawat S.

Abstract

Bioassay-guided fractionation of the EtOAc extract of the roots of Thai Ziziphus oenoplia var. brunoniana resulted in the isolation of four new 13-membered cyclopeptide alkaloids of the 5(13) type, ziziphine N-Q. The structures of the new metabolites were elucidated on the basis of spectroscopic analyses and the stereochemical assignments were established by comparison with other related compounds of known stereochemistry. Ziziphine N and Q exhibited significant antiplasmodial activity against the parasite Plasmodium falciparum with the inhibitory concentration (IC50) values of 3.92 and 3.5 μg/mL, respectively. Ziziphine N and Q also demonstrated weak antimycobacterial activity against Mycobacterium tuberculosis with the same MIC value of 200 μg/mL. © 2004 Elsevier Ltd. All rights reserved.

Subject(s)

Alkaloid
 Antimalarial agent
 Antimycobacterial agent
 Cyclopeptide
 Plant extract
 Unclassified drug
 Ziziphine n
 Ziziphine o
 Ziziphine p
 Ziziphine q
 Article
 Controlled study
 Drug activity
 Drug isolation
 Drug structure
 Fractionation
 IC 50
 Jujube
 Minimum inhibitory concentration
 Mycobacterium tuberculosis
 Nonhuman
 Plant root
 Plasmodium falciparum
 Priority journal
 Spectroscopy
 Stereochemistry
 Mycobacterium
 Mycobacterium tuberculosis
 Plasmodium falciparum
 Rhamnaceae
 Ziziphus

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URI

https://hdl.handle.net/20.500.14740/6174

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Scopus: Year 1983-2021

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