Publication: Neuritogenic and neuroprotective activities of the essential oil from rhizomes of curcuma alismatifolia
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Issued Date
2019
Resource Type
File Type
application/pdf
ISSN
1934578X
Other identifier(s)
2-s2.0-85069655022
Rights Holder(s)
Scopus
Bibliographic Citation
Natural Product Communications. Vol 14, No.7 (2019)
Suggested Citation
Kochaphum S., Banyat P., Tadtong S., Sareedenchai V., Athikomkulchai S. Neuritogenic and neuroprotective activities of the essential oil from rhizomes of curcuma alismatifolia. Natural Product Communications. Vol 14, No.7 (2019). doi:10.1177/1934578X19864217 Retrieved from: https://hdl.handle.net/20.500.14740/5526
Abstract
The essential oil from rhizomes of Curcuma alismatifolia Gagnep. was extracted by hydrodistillation. Chemical analysis by gas chromatography- mass spectrometry identified 12 compounds, of which the most prominent were xanthorrhizol (82.2%), ar-curcumene (6.5%), α-cedrene (1.8%), and β-bisabolol (1.1%). The essential oil at 1 ng/mL showed neuroprotective and neuritogenic activity on P19-derived neurons by significantly enhancing cell viability, length, and branching numbers of the cultured P19-derived neurons. In addition, xanthorrhizol, the major compound of the essential oil, at 10 ng/mL also exhibited the protection of P19-derived neurons. However, the mechanism of their neuroprotective activity was not correlated with their antioxidant activity. © The Author(s) 2019.
Subject(s)
Alpha bergamotene
Alpha cedrene
Ar curcumene
Ascorbic acid
Beta bisabolol
Beta farnesene
Bisabolol
Camphene
Camphor
Cineole
Essential oil
Gamma curcumene
Pinene
Quercetin
Unclassified drug
Xanthorrhizol
Article
Cell viability
Controlled study
Curcuma
Curcuma alismatifolia
Drug activity
Drug identification
Hydrodistillation
Mass fragmentography
Nerve cell culture
Neuritogenic activity
Neuroprotection
Rhizome
Alpha cedrene
Ar curcumene
Ascorbic acid
Beta bisabolol
Beta farnesene
Bisabolol
Camphene
Camphor
Cineole
Essential oil
Gamma curcumene
Pinene
Quercetin
Unclassified drug
Xanthorrhizol
Article
Cell viability
Controlled study
Curcuma
Curcuma alismatifolia
Drug activity
Drug identification
Hydrodistillation
Mass fragmentography
Nerve cell culture
Neuritogenic activity
Neuroprotection
Rhizome