Publication:
Zinc protects SK-N-SH cells from methamphetamine-induced α-synuclein expression

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dc.contributor.authorAjjimaporn A.
dc.contributor.authorPhansuwan-Pujito P.
dc.contributor.authorEbadi M.
dc.contributor.authorGovitrapong P.
dc.date.accessioned2021-04-05T04:32:10Z
dc.date.available2021-04-05T04:32:10Z
dc.date.issued2007
dc.date.issuedBE2550
dc.description.abstractMethamphetamine (METH) is a well-known drug of abuse and neurotoxin that may cause temporary or permanent disturbances in the dopaminergic systems of the brain, predisposing individuals to Parkinsonism. Previously, we have shown that METH causes dopaminergic cell death by increasing the production of reactive oxygen species (ROS) and by depleting cellular ATP levels. These effects were abolished by pretreatment with ZnCl2 which enhanced expression of the zinc binding protein, metallothionein. In the present study, the effects of ZnCl2 on α-synuclein expression were examined further in METH-treated SK-N-SH cells in culture. We show that METH significantly increased α-synuclein expression in a dose-dependent manner after inducing oxidative stress. Pretreatment with ZnCl2 (50 μM) reversed this stimulatory effect. We propose that zinc mediates this neuroprotective response via the production of metallothionein. © 2007 Elsevier Ireland Ltd. All rights reserved.
dc.format.mimetypeapplication/pdf
dc.identifier.citationNeuroscience Letters. Vol 419, No.1 (2007), p.59-63
dc.identifier.doi10.1016/j.neulet.2007.03.073
dc.identifier.issn3043940
dc.identifier.other2-s2.0-34248206819
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4563
dc.rights.holderScopus
dc.subject.otherAlpha synuclein
dc.subject.otherMethamphetamine
dc.subject.otherZinc chloride
dc.subject.otherArticle
dc.subject.otherCell culture
dc.subject.otherCell stimulation
dc.subject.otherControlled study
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherNeuroblastoma cell
dc.subject.otherOxidative stress
dc.subject.otherPriority journal
dc.subject.otherProtein expression
dc.subject.otherAlpha-Synuclein
dc.subject.otherCell Line, Tumor
dc.subject.otherDopamine Agents
dc.subject.otherDose-Response Relationship, Drug
dc.subject.otherDrug Interactions
dc.subject.otherGene Expression
dc.subject.otherHumans
dc.subject.otherMethamphetamine
dc.subject.otherNeuroblastoma
dc.subject.otherZinc
dc.titleZinc protects SK-N-SH cells from methamphetamine-induced α-synuclein expression
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34248206819&doi=10.1016%2fj.neulet.2007.03.073&partnerID=40&md5=87c0876db4786345ae6feaaec4a97a24

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