Publication:
Zinc protects SK-N-SH cells from methamphetamine-induced α-synuclein expression

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Issued Date

2007

Resource Type

Article

File Type

application/pdf

ISSN

3043940

DOI

10.1016/j.neulet.2007.03.073

Other identifier(s)

2-s2.0-34248206819

Rights Holder(s)

Scopus

Bibliographic Citation

Neuroscience Letters. Vol 419, No.1 (2007), p.59-63

Suggested Citation

Ajjimaporn A., Phansuwan-Pujito P., Ebadi M., Govitrapong P. Zinc protects SK-N-SH cells from methamphetamine-induced α-synuclein expression. Neuroscience Letters. Vol 419, No.1 (2007), p.59-63. doi:10.1016/j.neulet.2007.03.073 Retrieved from: https://hdl.handle.net/20.500.14740/4563

Title

Zinc protects SK-N-SH cells from methamphetamine-induced α-synuclein expression

Author(s)

Ajjimaporn A.
 Phansuwan-Pujito P.
 Ebadi M.
 Govitrapong P.

Abstract

Methamphetamine (METH) is a well-known drug of abuse and neurotoxin that may cause temporary or permanent disturbances in the dopaminergic systems of the brain, predisposing individuals to Parkinsonism. Previously, we have shown that METH causes dopaminergic cell death by increasing the production of reactive oxygen species (ROS) and by depleting cellular ATP levels. These effects were abolished by pretreatment with ZnCl2 which enhanced expression of the zinc binding protein, metallothionein. In the present study, the effects of ZnCl2 on α-synuclein expression were examined further in METH-treated SK-N-SH cells in culture. We show that METH significantly increased α-synuclein expression in a dose-dependent manner after inducing oxidative stress. Pretreatment with ZnCl2 (50 μM) reversed this stimulatory effect. We propose that zinc mediates this neuroprotective response via the production of metallothionein. © 2007 Elsevier Ireland Ltd. All rights reserved.

Subject(s)

Alpha synuclein
 Methamphetamine
 Zinc chloride
 Article
 Cell culture
 Cell stimulation
 Controlled study
 Human
 Human cell
 Neuroblastoma cell
 Oxidative stress
 Priority journal
 Protein expression
 Alpha-Synuclein
 Cell Line, Tumor
 Dopamine Agents
 Dose-Response Relationship, Drug
 Drug Interactions
 Gene Expression
 Humans
 Methamphetamine
 Neuroblastoma
 Zinc

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URI

https://hdl.handle.net/20.500.14740/4563

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Scopus: Year 1983-2021

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