Publication:
Anxiety-like behaviour and c-fos expression in rats that inhaled vetiver essential oil

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Issued Date

2015

Resource Type

Article

File Type

application/pdf

ISSN

14786419

DOI

10.1080/14786419.2014.992342

Other identifier(s)

2-s2.0-84942248560

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Natural Product Research. Vol 29, No.22 (2015), p.2141-2144

Suggested Citation

Saiyudthong S., Pongmayteegul S., Marsden C.A., Phansuwan-Pujito P. Anxiety-like behaviour and c-fos expression in rats that inhaled vetiver essential oil. Natural Product Research. Vol 29, No.22 (2015), p.2141-2144. doi:10.1080/14786419.2014.992342 Retrieved from: https://hdl.handle.net/20.500.14740/6018

Title

Anxiety-like behaviour and c-fos expression in rats that inhaled vetiver essential oil

Author(s)

Saiyudthong S.
 Pongmayteegul S.
 Marsden C.A.
 Phansuwan-Pujito P.

Abstract

Vetiver essential oil (VEO) has been used in aromatherapy for relaxation. This study aimed to investigate the effects of VEO on an anxiety-related behavioural model (the elevated plus-maze, EPM) and immediate-early gene c-fos in amygdala, known to be involved in anxiety. Male Wistar rats were administered diazepam (1 mg/kg i.p.) for 30 min or inhalated with VEO (1%, 2.5% or 5% w/w) for 7 min prior to exposure to the EPM. Then, the effects of 2.5% VEO, the anxiolytic dose, on c-fos expression in amygdala were investigated. The rats given either 2.5% VEO or diazepam exhibited an anxiolytic-like profile in the EPM. VEO and diazepam significantly increased c-fos expression in the lateral division of the central amygdaloid nucleus (CeL). Therefore, the anxiolytic properties of VEO might be associated with altering neuronal activation in CeL. However, future studies are needed to investigate the precise mechanism of action of VEO. © 2015 Taylor & Francis.

Subject(s)

Anxiolytic agent
 Diazepam
 Essential oil
 Protein c fos
 Unclassified drug
 Vetiver essential oil
 Anxiolytic agent
 Diazepam
 Essential oil
 Protein c fos
 Amygdaloid nucleus
 Animal experiment
 Anxiety
 Article
 Central nucleus (amygdala)
 Controlled study
 Elevated plus maze test
 Gene expression
 Immediate early gene
 Male
 Nonhuman
 Oncogene c fos
 Rat
 Vetiveria
 Animal
 Anxiety
 Aromatherapy
 Chemistry
 Drug effects
 Drug therapy
 Inhalational drug administration
 Mental stress
 Metabolism
 Vetiveria
 Wistar rat
 Administration, Inhalation
 Amygdala
 Animals
 Anti-Anxiety Agents
 Anxiety
 Aromatherapy
 Diazepam
 Male
 Oils, Volatile
 Proto-Oncogene Proteins c-fos
 Rats, Wistar
 Stress, Psychological
 Vetiveria

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URI

https://hdl.handle.net/20.500.14740/6018

Collections

Scopus: Year 1983-2021

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