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Curcumin composite particles prepared by spray drying and in vitro anti-cancer activity on lung cancer cell line

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dc.contributor.authorThongnopkoon T.
dc.contributor.authorChittasupho C.
dc.date.accessioned2021-04-05T03:22:42Z
dc.date.available2021-04-05T03:22:42Z
dc.date.issued2018
dc.date.issuedBE2561
dc.description.abstractThis study was aimed to prepare curcumin composite particles by spray drying to improve the dissolution of curcumin and subsequently to determine the anti-cancer activity of the composite particles. The composite particles containing various proportions of curcumin, lactose monohydrate and a selected polymer, i.e. hydroxypropylmethylcellulose15LV (HPMC15LV) or polyvinylpyrrolidone-K30 (PVP-K30), were fabricated by spray drying with a specific condition. The particle size of the particles was mostly smaller than 10 microns. The physicochemical characterizations suggested that the composite particles were amorphous and showed molecular interaction between curcumin and the incorporated polymers. Type and proportion of incorporated polymers affected the curcumin content and the curcumin release. The composite particles using HPMC15LV showed a faster release rate than that of using PVP-K30 and they markedly showed a significantly higher dissolution rate than the unprocessed curcumin powder. The anti-cancer activity on lung cancer cells (A549 cells) showed that the composite particles using HPMC15LV exhibited the activity to decrease the percentage of survival cancer cells and its activity was superior to that of unprocessed curcumin. In conclusion, the spray dried composite particles containing curcumin might be employed as a delivery system to treat cancer because of their suitably physicochemical properties and anti-cancer activity. © 2018 Elsevier B.V.
dc.format.mimetypeapplication/pdf
dc.identifier.citationJournal of Drug Delivery Science and Technology. Vol 45, No. (2018), p.397-407
dc.identifier.doi10.1016/j.jddst.2018.04.006
dc.identifier.issn17732247
dc.identifier.other2-s2.0-85045285477
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4326
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherCurcumin
dc.subject.otherDoxorubicin
dc.subject.otherHydroxypropylmethylcellulose
dc.subject.otherLactose
dc.subject.otherPolymer
dc.subject.otherPovidone
dc.subject.otherA-549 cell line
dc.subject.otherAntineoplastic activity
dc.subject.otherApoptosis
dc.subject.otherArticle
dc.subject.otherCell proliferation assay
dc.subject.otherCell survival
dc.subject.otherCell viability
dc.subject.otherControlled study
dc.subject.otherDifferential scanning calorimetry
dc.subject.otherDrug cytotoxicity
dc.subject.otherDrug formulation
dc.subject.otherDrug solubility
dc.subject.otherIn vitro study
dc.subject.otherInfrared spectroscopy
dc.subject.otherLung cancer cell line
dc.subject.otherMolecular interaction
dc.subject.otherParticle size
dc.subject.otherPhysical chemistry
dc.subject.otherScanning electron microscopy
dc.subject.otherSpray drying
dc.subject.otherX ray powder diffraction
dc.titleCurcumin composite particles prepared by spray drying and in vitro anti-cancer activity on lung cancer cell line
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85045285477&doi=10.1016%2fj.jddst.2018.04.006&partnerID=40&md5=77324eea6aa144fcfd5e04cc17c6895b

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