Publication:
Curcumin composite particles prepared by spray drying and in vitro anti-cancer activity on lung cancer cell line

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Issued Date

2018

Resource Type

Article

File Type

application/pdf

ISSN

17732247

DOI

10.1016/j.jddst.2018.04.006

Other identifier(s)

2-s2.0-85045285477

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of Drug Delivery Science and Technology. Vol 45, No. (2018), p.397-407

Suggested Citation

Thongnopkoon T., Chittasupho C. Curcumin composite particles prepared by spray drying and in vitro anti-cancer activity on lung cancer cell line. Journal of Drug Delivery Science and Technology. Vol 45, No. (2018), p.397-407. doi:10.1016/j.jddst.2018.04.006 Retrieved from: https://hdl.handle.net/20.500.14740/4326

Title

Curcumin composite particles prepared by spray drying and in vitro anti-cancer activity on lung cancer cell line

Author(s)

Thongnopkoon T.
 Chittasupho C.

Abstract

This study was aimed to prepare curcumin composite particles by spray drying to improve the dissolution of curcumin and subsequently to determine the anti-cancer activity of the composite particles. The composite particles containing various proportions of curcumin, lactose monohydrate and a selected polymer, i.e. hydroxypropylmethylcellulose15LV (HPMC15LV) or polyvinylpyrrolidone-K30 (PVP-K30), were fabricated by spray drying with a specific condition. The particle size of the particles was mostly smaller than 10 microns. The physicochemical characterizations suggested that the composite particles were amorphous and showed molecular interaction between curcumin and the incorporated polymers. Type and proportion of incorporated polymers affected the curcumin content and the curcumin release. The composite particles using HPMC15LV showed a faster release rate than that of using PVP-K30 and they markedly showed a significantly higher dissolution rate than the unprocessed curcumin powder. The anti-cancer activity on lung cancer cells (A549 cells) showed that the composite particles using HPMC15LV exhibited the activity to decrease the percentage of survival cancer cells and its activity was superior to that of unprocessed curcumin. In conclusion, the spray dried composite particles containing curcumin might be employed as a delivery system to treat cancer because of their suitably physicochemical properties and anti-cancer activity. © 2018 Elsevier B.V.

Subject(s)

Curcumin
 Doxorubicin
 Hydroxypropylmethylcellulose
 Lactose
 Polymer
 Povidone
 A-549 cell line
 Antineoplastic activity
 Apoptosis
 Article
 Cell proliferation assay
 Cell survival
 Cell viability
 Controlled study
 Differential scanning calorimetry
 Drug cytotoxicity
 Drug formulation
 Drug solubility
 In vitro study
 Infrared spectroscopy
 Lung cancer cell line
 Molecular interaction
 Particle size
 Physical chemistry
 Scanning electron microscopy
 Spray drying
 X ray powder diffraction

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URI

https://hdl.handle.net/20.500.14740/4326

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Scopus: Year 1983-2021

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