Publication:
Kaempferia parviflora ethanolic extract promoted nitric oxide production in human umbilical vein endothelial cells

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Issued Date

2007

Resource Type

Article

File Type

application/pdf

ISSN

3788741

DOI

10.1016/j.jep.2006.09.037

Other identifier(s)

2-s2.0-33947122236

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Ethnopharmacology. Vol 110, No.3 (2007), p.559-562

Suggested Citation

Wattanapitayakul S.K., Suwatronnakorn M., Chularojmontri L., Herunsalee A., Niumsakul S., Charuchongkolwongse S., Chansuvanich N. Kaempferia parviflora ethanolic extract promoted nitric oxide production in human umbilical vein endothelial cells. Journal of Ethnopharmacology. Vol 110, No.3 (2007), p.559-562. doi:10.1016/j.jep.2006.09.037 Retrieved from: https://hdl.handle.net/20.500.14740/4688

Title

Kaempferia parviflora ethanolic extract promoted nitric oxide production in human umbilical vein endothelial cells

Author(s)

Wattanapitayakul S.K.
 Suwatronnakorn M.
 Chularojmontri L.
 Herunsalee A.
 Niumsakul S.
 Charuchongkolwongse S.
 Chansuvanich N.

Abstract

The rhizomes of Kaempferia parviflora (KP) (Zingiberaceae) have been used in Thai traditional medicine for health promotion and for the treatment of digestive disorders and gastric ulcer. This study investigated effect of KP on endothelial function. Studies in human umbilical vein endothelial cells (HUVEC) showed that KP dose-dependently increased nitrite concentrations in culture media after 48 h incubation. eNOS mRNA and protein expression were also enhanced. The induction of eNOS mRNA was detected at 4 h and plateau at 48 h while iNOS expression was not observed. These data demonstrate that KP has a great potential for a supplemental use in vascular endothelial health promotion. © 2006 Elsevier Ireland Ltd. All rights reserved.

Subject(s)

Alcohol
 Endothelial nitric oxide synthase
 Kaempferia parviflora extract
 Messenger RNA
 Nitric oxide
 Nitrite
 Plant extract
 Unclassified drug
 Article
 Concentration response
 Controlled study
 Endothelium cell
 Gastrointestinal disease
 Gene expression
 Gene induction
 Health promotion
 Human
 Human cell
 Kaempferia parviflora
 Medicinal plant
 Nonhuman
 Nucleotide sequence
 Protein expression
 Rhizome
 Stomach ulcer
 Traditional medicine
 Vascular endothelium
 Zingiberaceae
 Dose-Response Relationship, Drug
 Endothelial Cells
 Gene Expression Regulation
 Humans
 Medicine, Oriental Traditional
 Nitric Oxide
 Nitric Oxide Synthase Type II
 Nitric Oxide Synthase Type III
 Nitrites
 Phytotherapy
 Plant Extracts
 Plants, Medicinal
 Rhizome
 RNA, Messenger
 Thailand
 Umbilical Veins
 Zingiberaceae
 Kaempferia parviflora
 Zingiberaceae

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URI

https://hdl.handle.net/20.500.14740/4688

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Scopus: Year 1983-2021

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